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Unusual Causes of Stroke - Hypercoagulable States and their work-up

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Anticardiolipin Antibody Syndrome:<br />

Unanswered Questions<br />

• To what extent should therapy be individualized?<br />

• How does one monitor treatment effect?<br />

• Should one begin treatment with platelet inhibitors?<br />

• If one needs to use warfarin, what INR?<br />

– Anticoagulation t coagu at o to INR N 3-4.5 3 .5 not ot shown s ow s<strong>up</strong>erior s<strong>up</strong>e o in co controlled t o ed<br />

trials<br />

– INR <strong>of</strong> 3-4 increased risk <strong>of</strong> hemorrhage<br />

• At what point should one use immunos<strong>up</strong>pression?<br />

• Which immunos<strong>up</strong>pressive regimen should one use?

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