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Unusual Causes of Stroke - Hypercoagulable States and their work-up

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Antiphospholipid Antibody<br />

Syndrome: Treatment<br />

• Antiplatelet therapy<br />

– Clearly ineffective in many patients<br />

• AAnticoagulation ti l ti<br />

• INR 2-3<br />

• INR 3-4<br />

• IImmunos<strong>up</strong>pressive i treatment<br />

– Prednisone<br />

– IVIgG / Plasma exchange<br />

– Cyclophosphamide (may not affect antibody titers)<br />

– Rituximab<br />

• Only y<br />

limited data from controlled trials

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