Unusual Causes of Stroke - Hypercoagulable States and their work-up

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Anticardiolipin Antibodies: History • 1964: Bowie: – Association of lupus p anticoagulant g and antibodies to cardiolipin with venous thrombosis • 1972: “lupus anticoagulant” • 1983: First anticardiolipin antibody test • Subsequent association of anticardiolipin antibodies and lupus anticoagulant with stroke and other conditions
Antiphospholipid Antibody Syndrome • Is a syndrome, not a specific disease entity – Defined (by committee) on the basis of both clinical and immunological parameters – The definition probably does not cover the full spectrum of disease • Is a disease blessed (or cursed) by eponyms – Hughes syndrome, Asherton syndrome, Sneddon syndrome
Page 1 and 2: Unusual Causes of Stroke John EE. G
Page 3 and 4: TTopics to CCover • Anticardiolip
Page 5: Anticardiolipin Antibodies: History
Page 9 and 10: Antiphospholipid Antibody Syndrome
Page 11 and 12: Antiphospholipid Antibody Syndromes
Page 13 and 14: Antiphospholipid Antibodies: A Conc
Page 15 and 16: Antiphospholipid Antibodies: A Conc
Page 17 and 18: Antiphospholipid Antibodies: Major
Page 19 and 20: Antiphospholipid Antibodies: Associ
Page 21: Antiphospholipid Antibody Syndrome:
Page 24 and 25: SSneddon dd syndrome d • Antiphos
Page 26 and 27: Antiphospholipid Antibody and Strok
Page 28 and 29: Serological Diagnosis: Anticardioli
Page 30 and 31: Treatment
Page 32 and 33: PPossible bl New N Treatments T
Page 35 and 36: Hereditary Disorders of Coagulation
Page 37 and 38: Hereditary Abnormalities of Clottin
Page 39 and 40: Factor V Leiden and Deficiencies of
Page 41 and 42: Inherited Thrombophilia and Stroke
Page 43 and 44: Inherited Thrombophilia and Stroke
Page 45 and 46: RRare Causes C of f Stroke S k •
Page 47 and 48: Screening for Coagulopathies: Whom
Page 49 and 50: SSickle kl Cell C ll Hemoglobin H l
Page 51 and 52: SSickle kl Cell C ll Trait T and dD
Page 53 and 54: SStroke k in Sickle S kl Cell C ll
Page 55 and 56: SStroke k in Sickle S kl Cell C ll
Page 57 and 58:
Sickle Cell Trait: MRI in Children
Page 59 and 60:
SSickle kl Cell C ll Disease: D Tre
Page 61 and 62:
Sickle Cell Disease: Other Treatmen
Page 63 and 64:
Complications of Sickle Cell Trait
Page 65 and 66:
Reversible Cerebral Vasospasm Strok
Page 67 and 68:
Reversible Cerebral Vasospasm Syndr
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79:
Stroke Following Substance Abuse
Page 82 and 83:
Stroke Following Substance Abuse
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Cocaine • Usually cause stroke in
Page 86 and 87:
CCocaine-Induced I d dHHemorrhage h
Page 88 and 89:
Methamphetamine and Related Drugs
Page 93 and 94:
TTreatment: APASS Trial T l • Sub
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SSickle kl Cell C ll Disease D •
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TTreatment: APASS Trial T l • Sub
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• Encephalopathy and biopsy-prove
Page 103 and 104:
• Check TPA-pubmed CCocaine-induc
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IgA Anticardiolipin Antibodies: Sam
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Unusual Causes of Stroke - Hypercoagulable States and their work-up

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