Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
•http://en.wikipedia.org/wiki/Epoetin<br />
The history of rbc production<br />
•1906 PCarnot proposed rbc prodution regulated by hormones<br />
•Carnot and DeFlandre studied rbc production in rabbits/bloodletting expts<br />
•“hemopoietin” and purified<br />
•1970s JAdamson and JWEschenback: sheep and other animals- EPO and renal failure<br />
and EPO stimulating rbc production in bone marrow; treatment of human anemia<br />
•1980s Adamson, Eschenback et al: clinical trial for synthetic form of EPO: Epogen<br />
•1985 Lin et al isolated h-erythropietin gene from genomic phage library<br />
•Gene encoded erythropoietin that is biologically active in vitro and in vivo<br />
•Production of recombinant erythropoietin (RhEpo)<br />
•1989 FDA approves Epogen<br />
•2000 novel erythropoiesis stimulating protein (NESP) produced;<br />
•Glycoprotein with anti-anemic capabilities and longer half-life<br />
•Offers effect at a lower dose
Change language