Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
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•http://www.chinadaily.com.cn/china/2008-10/09/content_7088785.htm<br />
•http://www.npr.org/templates/story/story.php?storyId=95504782<br />
“Green Revolution”<br />
•Nobel 08, Chemistry<br />
•When exposed to uv light, protein glows green<br />
•Used as a tracer to expose movement<br />
•Mark particular cells in a tissue<br />
•Shows when and where particular genes turn on and off<br />
•“The Brainbow:” ‘spectacular experiment tags different nerve<br />
cells in the brain of a mouse’<br />
•Shimomura and a colleague (Woods Hole, MA and BU Medical School)<br />
isolated and characterized GFP from 10,000 jellyfish off the coast of WA in 1962<br />
•1990s: Chalfie constructed six individual nerve cells in C elegans to glow green<br />
•1990s: Tsien expanded the range of GFP-like proteins to express range of colors<br />
•-> Who constructed the gene?
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