Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
Lecture 7 - Genome Tools
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Mutagenesis<br />
•In vivo<br />
•In vitro<br />
•Mutations occur spontaneously<br />
•Single base changes in the genome<br />
•Indels<br />
•Duplications<br />
•Mutations occur in response to ‘stimulus’<br />
•Single base changes in the genome<br />
•Indels<br />
•Duplications<br />
•Mimic or expedite ‘naturally’ occurring mutations<br />
•Attractive given recombinant DNA technology<br />
•Overproduction and purification<br />
•“Make” better version<br />
What is the basis for changing parts of the genome? Cell? Individual?