2010 Neurological Institute Outcomes - Cleveland Clinic

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Epilepsy
Seizure Outcomes Following Epilepsy Surgery (Adult and Pediatric Patients)
Long-term chances of achieving and maintaining seizure freedom following various types of epilepsy surgery are shown in
the following graphs. Whenever possible, our data were compared to national published data. We used the widely accepted
Engel classification 6 of seizure freedom to classify our seizure outcomes (seizure-free = Engel class 1).
Long-Term Seizure Freedom in Adult and Pediatric Patients Following Epilepsy Surgery (N = 1,594)
Surgical Dates: 1996 – 2010
Seizure-free (%)
100
80
60
40
20
0
0 1 2 3 4 5 6 7 8 9 10 11 12
Years from Surgery
Pediatric Epilepsy Patients
Adult Epilepsy Patients
Combined Cohort
Years from Surgery 1 Year 2 Years 5 Years 10 Years 12 Years
% Seizure-free (overall group) 76% 71% 62% 50% 44%
% Seizure-free (adult epilepsy) 72% 66% 56% 48% 43%
% Seizure-free (pediatric epilepsy) 80% 76% 67% 50% 44%
Forty-four percent of patients with previously medically intractable epilepsy remained seizure-free 12 years after surgical
treatment at Cleveland Clinic’s Epilepsy Center. The overall curve of seizure outcomes shows similar long-term chances of
seizure freedom in adult and pediatric patients who underwent epilepsy surgery at the center from 1996 through 2010.
6. Engel J Jr., Van Ness PC, Rasmussen TB, Ojemann LM. Outcome with respect to epileptic seizures. In Surgical Treatment of the Epilepsies
(Engle J Jr., editor). 2nd ed. New York, NY:Raven Press; 1993:609-621.
Outcomes 2010