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Table 58: Deterministic base case analysis (in cancer patients) using <strong>the</strong> manufacturer’s<br />

assumptions (be<strong>for</strong>e amendment <strong>of</strong> errors identified in <strong>the</strong> model).<br />

LIFETIME (40 years) ICER estimate: dominant<br />

Costs<br />

<strong>Rivaroxaban</strong> LMWH/VKA Increment<br />

Drug cost £365 £1,146 -£781<br />

Monitor cost £0 £262 -£262<br />

Event costs £563 £535 £28<br />

Bleed cost £122 £196 -£74<br />

PTS/CTEPH £67 £63 £4<br />

Total Cost £1,117 £2,203 -£1,085<br />

Outcomes<br />

No <strong>of</strong> deaths 1.00 1.00 -0.00<br />

No VTEs 0.32 0.31 0.01<br />

No maj Bleeds 0.03 0.04 -0.01<br />

QALYs (discounted) 4.68 4.68 0.00135<br />

WTP = £20,000 WTP = £30,000<br />

NMB £1,112.35 £1,125.83<br />

Table 59: Deterministic base case analysis (in cancer patients) using <strong>the</strong> manufacturer’s<br />

assumptions after amendment <strong>of</strong> errors identified in <strong>the</strong> model.<br />

LIFETIME (40 years) ICER estimate: dominant<br />

Costs<br />

<strong>Rivaroxaban</strong> LMWH/VKA Increment<br />

Drug cost £365 £1,146 -£781<br />

Monitor cost £0 £449 -£449<br />

Event costs £725 £694 £30<br />

Bleed cost £122 £199 -£77<br />

PTS/CTEPH £91 £87 £4<br />

Total Cost £1,303 £2,574 -£1,272<br />

Outcomes<br />

No <strong>of</strong> deaths 1.00 1.00 0.00<br />

No VTEs 0.35 0.34 0.01<br />

No maj Bleeds 0.03 0.04 -0.01<br />

QALYs (discounted) 4.63 4.63 0.00129<br />

WTP = £20,000 WTP = £30,000<br />

NMB £1,297.41 £1,310.27<br />

165<br />

Copyright 2012 Queen's Printer <strong>and</strong> Controller <strong>of</strong> HMSO. All rights reserved.

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