Rivaroxaban for the treatment of deep vein thrombosis and ...
Rivaroxaban for the treatment of deep vein thrombosis and ...
Rivaroxaban for the treatment of deep vein thrombosis and ...
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Table 60: Deterministic base case analysis (in cancer patients) using <strong>the</strong> manufacturer’s<br />
assumptions after amendment <strong>of</strong> errors identified in <strong>the</strong> model, using <strong>the</strong> mean HR<br />
assuming U(0,5)<br />
LIFETIME (40 years) ICER estimate: £34,865 per QALY sold<br />
Costs<br />
<strong>Rivaroxaban</strong> LMWH/VKA Increment<br />
Drug cost £365 £1,242 -£876<br />
Monitor cost £0 £490 -£490<br />
Event costs £725 £633 £91<br />
Bleed cost £122 £0 £122<br />
PTS/CTEPH £91 £78 £13<br />
Total Cost £1,303 £2,443 -£1,141<br />
Outcomes<br />
No <strong>of</strong> deaths 1.00 1.00 0.00<br />
No VTEs 0.35 0.32 0.03<br />
No maj Bleeds 0.03 0.00 0.03<br />
QALYs (discounted) 4.63 4.66 -0.03272<br />
WTP = £20,000 WTP = £30,000<br />
NMB £486.33 £159.16<br />
Table 61: Deterministic base case analysis (in cancer patients) using <strong>the</strong> manufacturer’s<br />
assumptions after amendment <strong>of</strong> errors identified in <strong>the</strong> model, using <strong>the</strong> mean HR<br />
assuming U(0,2)<br />
LIFETIME (40 years) ICER estimate: £75,408 per QALY yielded<br />
Costs<br />
<strong>Rivaroxaban</strong> LMWH/VKA Increment<br />
Drug cost £365 £1,192 -£826<br />
Monitor cost £0 £468 -£468<br />
Event costs £725 £668 £56<br />
Bleed cost £122 £94 £28<br />
PTS/CTEPH £91 £83 £8<br />
Total Cost £1,303 £2,505 -£1,202<br />
Outcomes<br />
No <strong>of</strong> deaths 1.00 1.00 0.00<br />
No VTEs 0.35 0.33 0.02<br />
No maj Bleeds 0.03 0.02 0.01<br />
QALYs (discounted) 4.63 4.64 -0.01594<br />
WTP = £20,000 WTP = £30,000<br />
NMB £883.34 £723.91<br />
166<br />
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