CHEM01200604012 Dibakar Goswami - Homi Bhabha National ...

CONTENTS
SYNOPSIS
LIST OF FIGURES
LIST OF TABLES
i-xxii
xxiii-xxvi
xxvii
CHAPTER I
INTRODUCTION
I.1 Preamble 1
I.2 Introduction to Chirality and Asymmetric Synthesis 3
I.3 Strategies of Enantiomeric Synthesis 6
CHAPTER II
[BMIM][Br]: A GREEN AND EFFICIENT MEDIA
FOR ALLYLATION OF CARBONYLS
II.1 Introduction to Chiral Carbinols 20
II.2
Introduction to Homoallylic Alcohols: Allylation of 31
Carbonyls
II.3
Present Work
II.3.1 Introduction to Ionic Liquids 36
II.3.2 Indium Mediated Allylation in [bmim][Br] 39
II.3.3 Gallium Mediated Allylation in [bmim][Br] 54
II.4 Experimental Section 69
CHAPTER III
DIASTEREOSELECTIVE SYNTHESIS OF CHIRAL
CARBINOLS
III.1
Diastereoselective Synthesis of Chiral Carbinols via
Bi-metallic Redox Strategies
III.1.1 Introduction 75
III.1.2 Present Work 76
III.2
Metal Dependent Modulation of Diastereoselectivity
in the Barbier Type Allylation/ Crotylation
III.2.1 Present Work 110
III.3 Experimental Section 119
CHAPTER IV ASYMMETRIC SYNTHESIS OF SOME BIO-
ACTIVE ORGANIC COMPOUNDS
IV.1
Synthesis of Enantiopure (R)-Arundic Acid
IV.1.1 Introduction 138
IV.1.2 Previous Syntheses 139
IV.1.3 Present Work 142
IV.2
Synthesis of Octadienoic Acid Unit of Cryptophycins