BioProcess Product Guide - GE Healthcare Life Sciences

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Products and platforms across bioprocessing Through continuous development of innovative products and with the recent acquisition of PAA Laboratories, we are able to support bioprocessing from cell culture and fermentation through recovery and purification to formulation. Our products and platform solutions are designed to meet the key challenges posed at every stage in the process, delivering the desired product at the required purity and safety: all with fast development and integrated solutions in mind. 14 www.gelifesciences.com/bioprocess
Key goals Technology Key products Downstream Upstream Cell Culture Recovery Capture Purification • High product titer • Product folding & post translational modifications correct • Product easily transferred to DSP • Isolate and prepare product for purification • Removal of cells and cells debris • Secure process robustness & economy • Initial purification of target molecule • Removal of process related impurities from clarified feed, including host cell protein, DNA, viruses and endotoxins • High producer cell grown in reactors and fermenters • Cell disruption methods • Cross flow filtration • Normal flow filtration • Affinity chromatography • Ion exchange • Multi-modal • Ion exchange chromatography • Multi-modal • Hydrophobic interaction • Ultrafiltration/ diafiltration • WAVE Bioreactor • WAVE Mixer • Microcarriers • ReadyCircuit • PAA cell culture media • PAA supplements • ULTA filters • ReadyToProcess hollow fibers • ReadyToProcess chromatography • MabSelect, Capto media • PreDictor formats • Sepharose, Sephadex, CDM media • UniFlux, ÄKTA systems, UNICORN • AxiChrom columns • ReadyToProcess chromatography • ReadyToProcess hollow fiber • Capto, PlasmidSelect, CDM media • Sepharose, Sephadex, SOURCE • PreDictor, HiScreen, AxiChrom columns • Kvick cassettes, hollow fibers • ÄKTA systems, UNICORN, UniFlux Polishing • Removal of remaining traces of process- and product-related impurities • Ion exchange • Reversed phase • Hydrophobic interaction • Gel filtration • ReadyToProcess chromatography • Capto ImpRes, Superdex prep grade • Sephacryl, Sepharose, SOURCE • UniFlux, ÄKTA systems • AxiChrom columns Formulation • Long-term product stability • Ultrafiltration/ diafiltration • Kvick cassettes, Hollow fiber filters • ReadyToProcess hollow fibers Analytics Manufacturing support Buffer preparation Cell culture media preparation QC/QA • Rapid, flexible preparation of buffer stock • Removal of bioburden and/or particulates • Consistent cell culture performance • Sterilization of heat labile components • Flexible preparation and storage systems • Rapid, selective measurement of target proteins or specific contaminants • Filtration • Mixing technology • Connectivity and storage solutions • Inline conditioning • Sterile filtration and mycoplasma removal • Mixing technology • Connectivity and storage solutions • Surface plasmon resonance • Ultrasensitive microcalorimetry • ULTA filters • WAVE Mixer • ReadyMate connectors • ReadyCircuit assemblies • ÄKTA Inline conditioning systems • ULTA filters • WAVE Mixer • ReadyMate connectors • ReadyCircuit assemblies • Biacore systems • MicroCal systems www.gelifesciences.com/bioprocess 15
Page 1 and 2: GE Healthcare Life Sciences BioProc
Page 3 and 4: North America Canada T: 1-800-463-5
Page 5 and 6: Sales branch offices Sweden GE Heal
Page 7 and 8: Main offices GE Healthcare Bio-Scie
Page 9 and 10: 4 5 6 Chromatography media 74 Ion e
Page 11 and 12: Time to market is key Transforming
Page 13: Regardless of the expression system
Page 18 and 19: 1 ReadyCircuit assemblies and Ready
Page 20 and 21: 1 PreDictor RoboColumn Product high
Page 22 and 23: 1 MabSelect SuRe LX Product highlig
Page 24 and 25: 1 MicroCal DSC systems Product high
Page 26 and 27: 2Cell culture Cell culture media, s
Page 28 and 29: 2 Cell culture media, sera and reag
Page 30 and 31: 2 Cell culture Network of competenc
Page 32 and 33: 2 Cell culture Cytodex 1 and 3 Cyto
Page 34 and 35: 3ReadyToProcess ReadyToProcess Plat
Page 36 and 37: 1 2 3 ReadyToProcess ReadyToProcess
Page 38 and 39: 1 WAVE Bioreactor systems 2 3 Ready
Page 40 and 41: 1 2 Overview - Systems Specificatio
Page 42 and 43: 1 2 3 ReadyToProcess WAVE Bioreacto
Page 44 and 45: 1 2 WAVE Bioreactor 2/10 system Ord
Page 46 and 47: 1 2 3 ReadyToProcess Ordering infor
Page 48 and 49: 1 WAVEPOD II Integrated Controller
Page 50 and 51: 1 2 3 ReadyToProcess WAVE Mixer WAV
Page 52 and 53: 1 2 Single-use fluid management and
Page 54 and 55: 1 ReadyCircuit bags Tube assemblies
Page 56 and 57: 1 2 3 ReadyToProcess Custom ReadyCi
Page 58 and 59: 1 2 3 ReadyToProcess Ordering infor
Page 60 and 61: 1 ReadyToProcess ULTA normal flow f
Page 62 and 63: 1 Ordering information ULTA normal
Page 64 and 65:
1 Ordering information ReadyKart ac
Page 66 and 67:
1 2 3 ReadyToProcess ReadyToProcess
Page 68 and 69:
1 2 3 ReadyToProcess Sterile Tube F
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1 ReadyToProcess chromatography 2 3
Page 72 and 73:
1 2 3 ReadyToProcess ReadyToProcess
Page 74:
4 Chromatography media Ion exchange
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Ion exchange chromatography Techniq
Page 79 and 80:
Selection guide Capture Polishing S
Page 81 and 82:
Sepharose XL High loading capacitie
Page 83 and 84:
MabSelect media The successful prod
Page 85 and 86:
Capture toolkit for antibody fragme
Page 87 and 88:
Hydrophobic interaction chromatogra
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Hydrophobicity map of HIC media But
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Capto Core 700 OH OH OH OH The mult
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PlasmidSelect Xtra S N The multimod
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Products SOURCE 15RPC and SOURCE 30
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Selection guide Capture Polishing S
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Application guide For very small mo
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Full-scale production and validatio
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Columns for process chromatography
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AxiChrom columns 5 Chromatography c
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Technical specifications AxiChrom 5
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Chromaflow columns 5 Chromatography
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Ordering information Chromaflow col
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BPG columns BPG columns are glass c
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5 Connecting the column to your sys
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5 Chromatography columns Accessorie
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5 Chromatography columns Spare part
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INdEX columns INdEX are easy-to-use
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Packing extension. Ordering informa
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FineLINE columns The FineLINE range
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Accessories for FineLINE Pilot 35 c
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A guide to plastic connectors for p
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HiScale columns 5 Chromatography co
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Custom-packed laboratory columns 5
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Manufacturing Solutions - column pa
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6 Chromatography systems ÄKTA avan
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ÄKTA avant system Security: reliab
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ÄKTAprocess system Versatile user
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Inline conditioning for process chr
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UNICORN control Among the many feat
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6 Chromatography systems OPC Connec
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7 Products for process development
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Products for process development 7
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PreDictor 96-well filter plates A)
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PreDictor RoboColumn 7 Process deve
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Examples of prepacked columns Affin
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Selection kits In addition to the i
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Systems for method and process deve
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8Filtration products Cross flow fil
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Filtration Cross flow filtration (C
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8 Filtration products Cross flow fi
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Cross flow filtration Kvick Start c
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Kvick Lab packets and Kvick Lab cas
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Kvick Lab packet holder The Packet
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Kvick Flow cassette holder Specific
Page 178 and 179:
MidGee cross flow cartridges Orderi
Page 180 and 181:
Xampler laboratory cartridges 8 Fil
Page 182 and 183:
Ordering information for pilot scal
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Ordering information for process sc
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Ordering information for MaxCell pr
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Steam-in-place hollow fiber cartrid
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ULTA Pure HC The inherent low prote
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ULTA Prime GF ULTA Prime GF cartrid
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Filtration hardware ÄKTAcrossflow
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Ordering information UniFlux system
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Ordering information Code Number Ca
Page 200 and 201:
9Protein interaction and stability
Page 202 and 203:
Biacore systems Protein interaction
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Biacore C Validation support Biacor
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MicroCal systems Ultrasensitive mic
Page 208 and 209:
10 Oligonucleotide synthesis Synthe
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Oligonucleotide synthesis Oligonucl
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OligoProcess OligoProcess systems a
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Solid supports Polystyrene-based su
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11 Service and support Service agre
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Service agreements Life Sciences Se
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Application services - Fast Trak Us
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List of standard courses available
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Validation Services Validation Serv
Page 226 and 227:
Online regulatory and technical sup
Page 228 and 229:
System and column support Spare par
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Literature There is a wealth of lit
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12 Index and legal A to Z of media
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■ ANX Sepharose 4 Fast Flow (low
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■ Butyl-S Sepharose 6 Fast Flow.
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■ Capto DEAE. See p 78-81, 160 Pa
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■ Capto Q. See p 78-81, 160 Pack
Page 243 and 244:
■ Chelating Sepharose Fast Flow.
Page 245 and 246:
Cytodex 3. See p 31-32 Pack size Co
Page 247 and 248:
Glutathione Sepharose 4 Fast Flow.
Page 249 and 250:
■ MabSelect. See p 83, 86 Pack si
Page 251 and 252:
CDM MacroCap Q. See p 78, 80, 101 P
Page 253 and 254:
Oligosynt. See Solid supports for o
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■ rProtein A Sepharose 4 Fast Flo
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■ Q Sepharose High Performance. S
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■ Sephadex G-25 Coarse. See p 98-
Page 261 and 262:
■ Sepharose 4 Fast Flow. See p 98
Page 263 and 264:
■ SOURCE 15S. See p 79, 81 Pack s
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■ SP Sepharose XL. See p 81, 160
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Index and legal 12 www.gelifescienc
Page 269 and 270:
5. Delivery/Installation/Acceptance
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Trademarks GE Healthcare trademarks
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CM Sephadex C-25 80, 243 CM Sephade
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Media selection strategy 76 Media t
Page 277 and 278:
SP Sepharose High Performance 81, 1
Page 280:
Notes
Page 284:
GE Healthcare Life Sciences For loc
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