BioProcess Product Guide - GE Healthcare Life Sciences

Steam-in-place hollow fiber cartridges
Steam-in-place hollow fiber cartridges/housings (STM style)
• Strong polysulfone cartridge elements
• Leak-proof, sanitary closure
• Available in UF and MF pore sizes
Polysulfone cartridge elements have the strength and
integrity to withstand the rigors of steam-in-place
operations. Cartridges slip into stainless steel housings for
safety and containment. A double O-ring seal at the inlet
and outlet of the cartridge element ensures leak-proof,
sanitary closure within the housing.
The element design allows quick yet thorough steam
penetration of the membranes. Furthermore, all cartridge
components are USP Class VI tested. Cartridges are
available in both ultrafiltration (UF) and microfiltration (MF)
pore sizes in a choice of cartridge lengths.
STM cartridge ordering information
STM ultrafiltration cartridges
Code number Model number Pore size Fiber ID Membrane area
(NMWC) (mm) (m 2 ) (ft 2 )
56-4104-13 UFP-30-E-35STM 30 000 1 0.8 8.5
56-4104-14 UFP-100-E-35STM 100 000 1 0.8 8.5
56-4104-27 UFP-500-E-55STM 500 000 1 2.1 23
56-4104-20 UFP-10-C-55STM 10 000 0.5 3.25 35
56-4104-22 UFP-30-C-55STM 30 000 0.5 3.25 35
56-4104-24 UFP-50-C-55STM 50 000 0.5 3.25 35
56-4104-25 UFP-100-C-55STM 100 000 0.5 3.25 35
STM microfiltration cartridges
Code number Model number Pore size Fiber ID Membrane area
(μm) (mm) (m 2 ) (ft 2 )
56-4104-28 CFP-1-E-55STM 0.1 1 2.1 23
56-4104-29 CFP-2-E-55STM 0.2 1 2.1 23
56-4104-30 CFP-4-E-55STM 0.45 1 2.1 23
Accessories for STM steam-in-place cartridges
Code number Model number Description
56-4109-94 KG4S 0.5 in TC gasket, silicone, pack of 4
56-4109-96 KG12S 1.5 in TC gasket, silicone, pack of 4
11-0005-25 KG24S 3 in TC [schedule 5 pipe] gasket, silicone, pack of 4
56-4106-65 CL4 0.5 in TC quick disconnect clamp, 304 SS
56-4106-67 CL12 1.5 in TC quick disconnect clamp, 304 SS
56-4106-71 CL24 3 in TC [schedule 5 pipe] clamp, 304 SS
56-4106-90 K02ORS STM O-ring set, silicone, pack of 8
56-4105-90 VPC4 0.5 in TC permeate-side condensate drain or vent
valve, 316L SS
8
Filtration products
Technical specifications
Cartridge housing assembly
All housing assemblies are of 316L stainless steel with sanitary construction. The
O-ring material is silicone. The retentate and permeate ports are 1.5-in sanitary
clamp configuration allowing for quick and easy connection to steam and process
piping. In operation, the housing should be piped in a vertical orientation. It is
recommended to steam the complete element and housing assembly for 30 minutes
at 121°C to 123°C and at 1 barg (15 psig). Steam should be delivered to both sides of
the membrane to ensure full steam penetration and to minimize the delta P across
the membrane during the steam sterilization cycle. A 0.5-in sanitary clamp port
is positioned on the low point of the housing shell to ensure complete removal of
concentrate.
GE Healthcare offers a complete SIP protocol. To ensure that the cycle will support
the rigors of a full validation and maximize the cartridge lifetime, GE Healthcare
strongly suggests that customers adhere to all recommendations of the SIP protocol.
188 www.gelifesciences.com/bioprocess