BioProcess Product Guide - GE Healthcare Life Sciences

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1 MicroCal DSC systems Product highlights MicroCal Differential Scanning Calorimetry (DSC) systems help you to screen for changes in protein stability and provide critical guidance in protein engineering through pre-formulation, process development, to formulation of the final biopharmaceutical product. The technique measures heat absorbed by the sample as the protein unfolds during a controlled temperature increase and without the use of labels or artificial probes. The resulting measure of thermostability gives an indication of the protein’s long-term stability, without having to perform time-consuming accelerated stability studies. MicroCal DSC systems are designed to provide: • Selection of the most stable engineered antibody • Selection for the most stable protein storage conditions • Identification of the optimal elution conditions in antibody purification For more information, see page 206. Smart Asset Management Services Pharmaceutical and biotech companies face many challenges today, such as higher operational costs, regulatory pressures, and shrinking profit margins. For corporations, it is critical to reduce costs while improving scientific productivity. To help with these challenges, GE Healthcare offers an array of services, including the Smart Asset Management Services program, Performance Solutions, LEAN Six-Sigma, Fast Trak process development and facility validation services. Smart Asset Management Services (SAMS) is helping leading companies around the world meet the challenges of controlling costs and improving productivity in a difficult business environment. For more information on how GE Healthcare Smart Asset Management Services can help your company, visit www.gelifesciences.com/service Our SAMS program can help companies: • Reduce operating costs by up to 20% through the implementation of an asset management program • Deploy on-site service engineers to improve instrument uptime and output • Apply LEAN Six-Sigma to operations to enhance productivity • Remove administrative tasks from your scientists to allow increased scientific productivity • Gain access to innovative financing solutions • Facilitate informed decision-making on capital purchases, improve asset productivity, and reduce maintenance costs through Asset Intelligence Solutions 24 www.gelifesciences.com/bioprocess
www.gelifesciences.com/bioprocess 25
Page 1 and 2: GE Healthcare Life Sciences BioProc
Page 3 and 4: North America Canada T: 1-800-463-5
Page 5 and 6: Sales branch offices Sweden GE Heal
Page 7 and 8: Main offices GE Healthcare Bio-Scie
Page 9 and 10: 4 5 6 Chromatography media 74 Ion e
Page 11 and 12: Time to market is key Transforming
Page 13 and 14: Regardless of the expression system
Page 15 and 16: Key goals Technology Key products D
Page 18 and 19: 1 ReadyCircuit assemblies and Ready
Page 20 and 21: 1 PreDictor RoboColumn Product high
Page 22 and 23: 1 MabSelect SuRe LX Product highlig
Page 26 and 27: 2Cell culture Cell culture media, s
Page 28 and 29: 2 Cell culture media, sera and reag
Page 30 and 31: 2 Cell culture Network of competenc
Page 32 and 33: 2 Cell culture Cytodex 1 and 3 Cyto
Page 34 and 35: 3ReadyToProcess ReadyToProcess Plat
Page 36 and 37: 1 2 3 ReadyToProcess ReadyToProcess
Page 38 and 39: 1 WAVE Bioreactor systems 2 3 Ready
Page 40 and 41: 1 2 Overview - Systems Specificatio
Page 42 and 43: 1 2 3 ReadyToProcess WAVE Bioreacto
Page 44 and 45: 1 2 WAVE Bioreactor 2/10 system Ord
Page 46 and 47: 1 2 3 ReadyToProcess Ordering infor
Page 48 and 49: 1 WAVEPOD II Integrated Controller
Page 50 and 51: 1 2 3 ReadyToProcess WAVE Mixer WAV
Page 52 and 53: 1 2 Single-use fluid management and
Page 54 and 55: 1 ReadyCircuit bags Tube assemblies
Page 56 and 57: 1 2 3 ReadyToProcess Custom ReadyCi
Page 58 and 59: 1 2 3 ReadyToProcess Ordering infor
Page 60 and 61: 1 ReadyToProcess ULTA normal flow f
Page 62 and 63: 1 Ordering information ULTA normal
Page 64 and 65: 1 Ordering information ReadyKart ac
Page 68 and 69: 1 2 3 ReadyToProcess Sterile Tube F
Page 70 and 71: 1 ReadyToProcess chromatography 2 3
Page 74:
4 Chromatography media Ion exchange
Page 77 and 78:
Ion exchange chromatography Techniq
Page 79 and 80:
Selection guide Capture Polishing S
Page 81 and 82:
Sepharose XL High loading capacitie
Page 83 and 84:
MabSelect media The successful prod
Page 85 and 86:
Capture toolkit for antibody fragme
Page 87 and 88:
Hydrophobic interaction chromatogra
Page 89 and 90:
Hydrophobicity map of HIC media But
Page 91 and 92:
Capto Core 700 OH OH OH OH The mult
Page 93 and 94:
PlasmidSelect Xtra S N The multimod
Page 95 and 96:
Products SOURCE 15RPC and SOURCE 30
Page 97 and 98:
Selection guide Capture Polishing S
Page 99 and 100:
Application guide For very small mo
Page 101 and 102:
Full-scale production and validatio
Page 104 and 105:
Columns for process chromatography
Page 106 and 107:
AxiChrom columns 5 Chromatography c
Page 108 and 109:
Technical specifications AxiChrom 5
Page 110 and 111:
Chromaflow columns 5 Chromatography
Page 112 and 113:
Ordering information Chromaflow col
Page 114 and 115:
BPG columns BPG columns are glass c
Page 116 and 117:
5 Connecting the column to your sys
Page 118 and 119:
5 Chromatography columns Accessorie
Page 120 and 121:
5 Chromatography columns Spare part
Page 122 and 123:
INdEX columns INdEX are easy-to-use
Page 124 and 125:
Packing extension. Ordering informa
Page 126 and 127:
FineLINE columns The FineLINE range
Page 128 and 129:
Accessories for FineLINE Pilot 35 c
Page 130 and 131:
A guide to plastic connectors for p
Page 132 and 133:
HiScale columns 5 Chromatography co
Page 134 and 135:
Custom-packed laboratory columns 5
Page 136 and 137:
Manufacturing Solutions - column pa
Page 138 and 139:
6 Chromatography systems ÄKTA avan
Page 140 and 141:
ÄKTA avant system Security: reliab
Page 142 and 143:
ÄKTAprocess system Versatile user
Page 144 and 145:
Inline conditioning for process chr
Page 146 and 147:
UNICORN control Among the many feat
Page 148 and 149:
6 Chromatography systems OPC Connec
Page 150 and 151:
7 Products for process development
Page 152 and 153:
Products for process development 7
Page 154 and 155:
PreDictor 96-well filter plates A)
Page 156 and 157:
PreDictor RoboColumn 7 Process deve
Page 158 and 159:
Examples of prepacked columns Affin
Page 160 and 161:
Selection kits In addition to the i
Page 162 and 163:
Systems for method and process deve
Page 164 and 165:
8Filtration products Cross flow fil
Page 166 and 167:
Filtration Cross flow filtration (C
Page 168 and 169:
8 Filtration products Cross flow fi
Page 170 and 171:
Cross flow filtration Kvick Start c
Page 172 and 173:
Kvick Lab packets and Kvick Lab cas
Page 174 and 175:
Kvick Lab packet holder The Packet
Page 176 and 177:
Kvick Flow cassette holder Specific
Page 178 and 179:
MidGee cross flow cartridges Orderi
Page 180 and 181:
Xampler laboratory cartridges 8 Fil
Page 182 and 183:
Ordering information for pilot scal
Page 184 and 185:
Ordering information for process sc
Page 186 and 187:
Ordering information for MaxCell pr
Page 188 and 189:
Steam-in-place hollow fiber cartrid
Page 190 and 191:
ULTA Pure HC The inherent low prote
Page 192 and 193:
ULTA Prime GF ULTA Prime GF cartrid
Page 194 and 195:
Filtration hardware ÄKTAcrossflow
Page 196 and 197:
Ordering information UniFlux system
Page 198 and 199:
Ordering information Code Number Ca
Page 200 and 201:
9Protein interaction and stability
Page 202 and 203:
Biacore systems Protein interaction
Page 204 and 205:
Biacore C Validation support Biacor
Page 206 and 207:
MicroCal systems Ultrasensitive mic
Page 208 and 209:
10 Oligonucleotide synthesis Synthe
Page 210 and 211:
Oligonucleotide synthesis Oligonucl
Page 212 and 213:
OligoProcess OligoProcess systems a
Page 214 and 215:
Solid supports Polystyrene-based su
Page 216 and 217:
11 Service and support Service agre
Page 218 and 219:
Service agreements Life Sciences Se
Page 220 and 221:
Application services - Fast Trak Us
Page 222 and 223:
List of standard courses available
Page 224 and 225:
Validation Services Validation Serv
Page 226 and 227:
Online regulatory and technical sup
Page 228 and 229:
System and column support Spare par
Page 230 and 231:
Literature There is a wealth of lit
Page 232:
12 Index and legal A to Z of media
Page 235 and 236:
■ ANX Sepharose 4 Fast Flow (low
Page 237 and 238:
■ Butyl-S Sepharose 6 Fast Flow.
Page 239 and 240:
■ Capto DEAE. See p 78-81, 160 Pa
Page 241 and 242:
■ Capto Q. See p 78-81, 160 Pack
Page 243 and 244:
■ Chelating Sepharose Fast Flow.
Page 245 and 246:
Cytodex 3. See p 31-32 Pack size Co
Page 247 and 248:
Glutathione Sepharose 4 Fast Flow.
Page 249 and 250:
■ MabSelect. See p 83, 86 Pack si
Page 251 and 252:
CDM MacroCap Q. See p 78, 80, 101 P
Page 253 and 254:
Oligosynt. See Solid supports for o
Page 255 and 256:
■ rProtein A Sepharose 4 Fast Flo
Page 257 and 258:
■ Q Sepharose High Performance. S
Page 259 and 260:
■ Sephadex G-25 Coarse. See p 98-
Page 261 and 262:
■ Sepharose 4 Fast Flow. See p 98
Page 263 and 264:
■ SOURCE 15S. See p 79, 81 Pack s
Page 265 and 266:
■ SP Sepharose XL. See p 81, 160
Page 267 and 268:
Index and legal 12 www.gelifescienc
Page 269 and 270:
5. Delivery/Installation/Acceptance
Page 271 and 272:
Trademarks GE Healthcare trademarks
Page 273 and 274:
CM Sephadex C-25 80, 243 CM Sephade
Page 275 and 276:
Media selection strategy 76 Media t
Page 277 and 278:
SP Sepharose High Performance 81, 1
Page 280:
Notes
Page 284:
GE Healthcare Life Sciences For loc
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