BioProcess Product Guide - GE Healthcare Life Sciences
BioProcess Product Guide - GE Healthcare Life Sciences
BioProcess Product Guide - GE Healthcare Life Sciences
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8<br />
Filtration products<br />
Cross flow filtration<br />
<strong>GE</strong> <strong>Healthcare</strong> separation cassettes and cartridges are<br />
designed for cross flow (tangential flow) operation. Unlike<br />
single pass or normal flow (dead end) filtration, cross flow<br />
filtration continuously sweeps the membrane surface<br />
by circulating the feed stream across it. This circulation<br />
minimizes blinding of the membrane pores and promotes<br />
consistent, long-term productivity. It also allows units to be<br />
cleaned, stored, and re-used as needed.<br />
As the feed stream is pumped through the cassette or<br />
cartridge, the retentate (the materials excluded by the<br />
membrane pores) continues through the recirculation<br />
loop, while the permeate, including solvent and solutes, is<br />
transported through the membrane pores and collected<br />
separately.<br />
Cross flow filtration format selection guide<br />
Attribute Hollow fiber Cassette<br />
Low binding Best Best<br />
Aseptic processing Best Good<br />
Reliable liner scale up Best Best<br />
High solids Best Good<br />
Low solids concentration Good Best<br />
Perfusion Best NR<br />
Cell clarification Best Good<br />
Plasma concentration Good Best<br />
Diafiltration Best Good<br />
Single use Good Good<br />
Laboratory scale Best Best<br />
Low hold up Good Best<br />
UF Best Best<br />
MF Best NA<br />
Steam-in-Place Best NR<br />
Multiple feed channel heights Best Limited<br />
Normal flow filtration<br />
<strong>GE</strong> <strong>Healthcare</strong> provides comprehensive normal flow<br />
filtration products designed to maximize process efficiency<br />
from early-phase product development through to full<br />
bioprocess production.<br />
Liquid sterilization<br />
Filters incorporating high-flow membrane formats minimize<br />
filtration system sizes while meeting full validation and<br />
integrity test requirements.<br />
Bioburden reduction<br />
Extensive range of membrane and depth media products<br />
meet individual application requirements.<br />
Clarification<br />
Range of absolute-rated, prefiltration products providing<br />
consistent performance with broad chemical compatibility.<br />
Range of Normal flow filtration filters<br />
Formats Prefilters Bio-burden<br />
reduction*<br />
Sterilizing grade<br />
Flat disc × × ×<br />
Capsules × × ×<br />
10 in cartridges × × ×<br />
20 in cartridges × × ×<br />
30 in cartridges × ×<br />
Pore sizes<br />
0.1 ×<br />
0.2 × ×<br />
0.45 ×<br />
0.65 ×<br />
1.0 ×<br />
3.0 ×<br />
5.0 ×<br />
10.0 ×<br />
20.0 ×<br />
* 1 to 5 Logs<br />
168 www.gelifesciences.com/bioprocess
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