Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
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25/11/2010<br />
Benzodiazepines / Pharmacodynamics (2)<br />
b. Cardiovascular system<br />
1. Produce a mild systemic vasodilation and<br />
reduction in cardiac output. Heart rate is<br />
usually unchanged.<br />
2. Hemodynamic changes may be pronounced<br />
in hypovolemic patients or in those with<br />
little cardiovascular reserve, if rapidly<br />
administered in a large dose, or if<br />
administered with an opioid.<br />
Benzodiazepines / Pharmacodynamics (3)<br />
c. Respiratory system<br />
1. Produce a mild dose-dependent decrease<br />
in respiratory rate and tidal volume.<br />
2. Respiratory depression may be<br />
pronounced if administered with an<br />
opioid, in patients with pulmonary disease,<br />
or in debilitated patients.<br />
11
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