Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
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25/11/2010<br />
<strong>Propofol</strong> / Pharmacodynamics (2)<br />
b. Cardiovascular system<br />
1. A cardiovascular depressant.<br />
2. Produces dose-dependent decreases in<br />
arterial blood pressure and cardiac output.<br />
3. Heart rate is minimally affected, and<br />
barostatic reflex is blunted.<br />
c. Respiratory system<br />
1. Produces a dose-dependent decrease in<br />
respiratory rate and tidal volume.<br />
2. Ventilatory response to hypercarbia<br />
is diminished.<br />
<strong>Propofol</strong> / Administration (1)<br />
a. Induction: 2.0 to 2.5 mg/kg g IV.<br />
b. Sedation: 25 to 75 µg/kg/min by IV infusion is<br />
often sufficient (titrate to effect).<br />
c. Maintenance of general anesthesia:<br />
100 to 150 µg/kg/min IV (titrate to effect).<br />
d. Reduce dosages in elderly or hemodynamically<br />
compromised patients or if<br />
administered with other anesthetics.<br />
7
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