Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
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25/11/2010<br />
Ketamine / Pharmacodynamics (1)<br />
a. Central nervous system (CNS)<br />
1. Produces a “dissociative” state<br />
accompanied by amnesia and profound<br />
analgesia.<br />
2. Increases cerebral blood flow, metabolic<br />
rate, and intracranial pressure.<br />
Ketamine / Pharmacodynamics (2)<br />
b. Cardiovascular system<br />
1. Increases heart rate and systemic and pulmonary<br />
artery blood pressure by causing release of<br />
endogenous catecholamines.<br />
2. Often used for induction of general anesthesia in<br />
hemodynamically compromised patients.<br />
3. May act as a myocardial depressant if<br />
administered in the presence of hypovolemia,<br />
autonomic nervous system blockade, or maximal<br />
sympathetic nervous system stimulation.<br />
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