Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
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25/11/2010<br />
Titration of <strong>anaesthetic</strong> depth<br />
(actual clinical practice)<br />
Inhaled <strong>anaesthetic</strong>s :<br />
VAPOR (vol%) ---- Inspired conc. ----- Endtidal conc. ----- drug<br />
effect<br />
<strong>Intravenous</strong> <strong>anaesthetic</strong>s :<br />
( “MAC” on line)<br />
Dose (mg/kg) --------????????? --------?????????? ------- drug<br />
effect<br />
Need for calculated (estimated) concentrations<br />
t 1/2 k e0 and time to peak effect<br />
Drug t 1/2 k e0 (min) Time to peak effect<br />
(min)<br />
<strong>Propofol</strong> 2.4 1.6 - 2.2<br />
Thiopental 1.5 1.7<br />
Midazolam 4.0 2.8<br />
Etomidate 1.5 2.0<br />
3
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