Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
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25/11/2010<br />
Barbiturates / Pharmacodynamics (1)<br />
a. Central nervous system (CNS)<br />
1. Produce unconsciousness but cause<br />
hyperalgesia in sub<strong>hypnotic</strong> doses.<br />
2. Produce a dose-dependent decrease in<br />
cerebral metabolism and blood flow and,<br />
at high doses, may produce an isoelectric<br />
electroencephalogram.<br />
Barbiturates / Pharmacodynamics (2)<br />
b. Cardiovascular system<br />
1. Decrease arterial blood pressure and<br />
cardiac output in a dose-dependent<br />
manner.<br />
2. May increase heart rate via baroceptor<br />
reflexes.<br />
c. Respiratory system<br />
Produce a dose-dependent decrease<br />
in respiratory rate and tidal volume.<br />
Apnea may result for 30 to 90 sec after<br />
a sleep dose.<br />
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