Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
Intravenous anaesthetic-hypnotic drugs Propofol Pentothal ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
25/11/2010<br />
GABA A Receptor<br />
• Transmembrane<br />
pentamer composed of 2<br />
α, 2 β, and 1 γ or δ<br />
subunits<br />
• Each has a binding site for<br />
GABA<br />
• Benzodiazepines<br />
• Bind a cleft of α and γ<br />
subunits<br />
• Increases frequency of<br />
channel opening<br />
• Barbiturates, (propofol)<br />
• Bind α subunit<br />
• Increase duration of<br />
channel opening<br />
• Agonist: muscimol<br />
• Antagonist: bicuculine<br />
<strong>Propofol</strong> / Characteristics (1)<br />
1. 2,6-diisopropylphenol is used for induction and<br />
maintenance of general anaesthesia.<br />
2. It is prepared as a 1% or 2% isotonic oil-in-water<br />
emulsion, which contains egg lecithin, glycerol,<br />
and soybean oil.<br />
3. Bacterial growth is inhibited by either ethylenediaminetetraacetic<br />
acid or sulfite.<br />
4. Mode of action: Increases activity at inhibitory<br />
γ-aminobutyric acid (GABA) synapses.<br />
5
Change language