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Clinical Guidelines for Acute Stroke Management - Living on the EDge

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4Introducti<strong>on</strong><br />

studies were identified during <strong>the</strong> development<br />

process regarding <strong>the</strong> impact of interventi<strong>on</strong>s <str<strong>on</strong>g>for</str<strong>on</strong>g><br />

cute stroke. Fur<strong>the</strong>r discussi<strong>on</strong> about <strong>the</strong><br />

socioec<strong>on</strong>omic impact of stroke is discussed in<br />

Secti<strong>on</strong> 9 of this document.<br />

Access is <strong>on</strong>e of <strong>the</strong> major barriers to equitable<br />

services and is influenced by geography, culture and<br />

spiritual beliefs. Particular challenges are <strong>the</strong>re<str<strong>on</strong>g>for</str<strong>on</strong>g>e<br />

noted <str<strong>on</strong>g>for</str<strong>on</strong>g> rural and remote services where resources,<br />

particularly human resources, may be limited. Whilst it<br />

is recognised that residents in rural and remote areas<br />

may have difficulty accessing health care as readily as<br />

<strong>the</strong>ir urban counterparts <strong>the</strong> aim in all settings must be<br />

to develop local soluti<strong>on</strong>s that ensure optimal practice<br />

and quality outcomes that are based <strong>on</strong> <strong>the</strong> best<br />

available evidence using <strong>the</strong> available resources.<br />

Careful c<strong>on</strong>siderati<strong>on</strong> is also required <str<strong>on</strong>g>for</str<strong>on</strong>g> <strong>the</strong> differing<br />

needs of people with stroke. Appropriate resources<br />

may be required in a variety of languages and <str<strong>on</strong>g>for</str<strong>on</strong>g>mats<br />

<str<strong>on</strong>g>for</str<strong>on</strong>g> people with stroke and <strong>the</strong>ir carers. The particular<br />

needs of people from Aboriginal and Torres Strait<br />

Islander and those from culturally and linguistically<br />

diverse backgrounds also require special attenti<strong>on</strong> and<br />

resources. 17 O<strong>the</strong>r groups of people (e.g. younger<br />

people with stroke) may also have specific needs that<br />

require particular resources or applicati<strong>on</strong> of <strong>the</strong>se<br />

guidelines.<br />

Format<br />

These guidelines are organised in nine secti<strong>on</strong>s to<br />

address issues deemed by <strong>the</strong> guideline developers<br />

as important in acute stroke care. The aim of <strong>the</strong><br />

guidelines is to provide a logical framework from<br />

pre-hospital care through to discharge and follow up<br />

in <strong>the</strong> community.<br />

The introducti<strong>on</strong> to each topic provides justificati<strong>on</strong><br />

<str<strong>on</strong>g>for</str<strong>on</strong>g> <strong>the</strong> recommendati<strong>on</strong>. The guidelines are <strong>the</strong>n<br />

presented in a box and are summarised according<br />

to <strong>the</strong> ‘interim’ NHMRC expanded levels of evidence<br />

which are listed below. 3 Each recommendati<strong>on</strong> is<br />

also graded according to <strong>the</strong> draft NHMRC grading<br />

system. The key references <str<strong>on</strong>g>for</str<strong>on</strong>g> each guideline are<br />

also included. Where no satisfactory Level I, II, III or IV<br />

evidence was available but <strong>the</strong>re was sufficient<br />

c<strong>on</strong>sensus, clinical practice points based <strong>on</strong> expert<br />

opini<strong>on</strong> is provided by <strong>the</strong> EWG. The group tried at all<br />

times to organise each secti<strong>on</strong> as a logical flow from<br />

assessment to management. As such <strong>the</strong> order of <strong>the</strong><br />

recommendati<strong>on</strong>s in each secti<strong>on</strong> is no indicati<strong>on</strong> of<br />

<strong>the</strong>ir importance.<br />

Designati<strong>on</strong>s of Levels of Evidence According to Type of Research Questi<strong>on</strong> 3<br />

LEVEL INTERVENTION DIAGNOSIS PROGNOSIS AETIOLOGY SCREENING<br />

i A systematic A systematic review of A systematic A systematic A systematic<br />

review of Level II Level II studies review of Level II review of Level II review of Level II<br />

studies studies studies<br />

ii A randomised A study of test accuracy A prospective A prospective A randomised<br />

c<strong>on</strong>trolled trial with: an independent, cohort study cohort study c<strong>on</strong>trolled trial<br />

blinded comparis<strong>on</strong> with a<br />

valid reference standard,<br />

am<strong>on</strong>g c<strong>on</strong>secutive patients<br />

with a defined clinical<br />

presentati<strong>on</strong><br />

iii-1 A A study of test accuracy All or n<strong>on</strong>e All or n<strong>on</strong>e A<br />

pseudorandomised with: an independent, pseudorandomised<br />

c<strong>on</strong>trolled trial blinded comparis<strong>on</strong> with a c<strong>on</strong>trolled trial<br />

(i.e. alternate valid reference standard, (i.e. alternate<br />

allocati<strong>on</strong> or some am<strong>on</strong>g n<strong>on</strong>-c<strong>on</strong>secutive allocati<strong>on</strong> or some<br />

o<strong>the</strong>r method) patients with a defined o<strong>the</strong>r method)<br />

clinical presentati<strong>on</strong><br />

c<strong>on</strong>t.

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