51st Annual Meeting & ToxExpo - Society of Toxicology

Society of Toxicology 2012
Scientific
Symposia
for specific interactions with immune system proteins or cells, and
understanding these interactions may allow exploitation of nanoparticle
properties to ensure both safety and efficacy of nanomedicines.
• Immunological Properties of Engineered Nanomaterials.
Marina A. Dobrovolskaia, SAIC-Frederick, Frederick, MD.
• Understanding the Immunological Properties of Functionalized
Lipid-Polymer Nanoparticles. Carolina Salvador-Morales, George
Mason University, Fairfax, VA.
• Recognition of Nanoparticles by Macrophages—From Principles
to Consequences and Toxicity. Anna Shvedova, NIOSH, West
Virginia University, Morgantown, WV.
• Development of CYT-6091 (Aurimune®): A Model Cancer
Nanomedicine. Lawrence Tamarkin, CytImmune, Rockville, MD.
• Case Study: Interaction of Dextran Nanomaterials with the
Immune System—In Vivo and In Vitro Studies.
Sandra Casinghino, Pfizer, Inc., Groton, CT.
Characterizing Toxic Modes of Action
and Pathways to Toxicity
Toxic Cell Death: Signaling Pathways, Cross-Talk,
and High-Throughput Analysis
Monday, March 12, 2:00 PM to 4:45 PM
Chairperson(s): Sten Orrenius, Karolinska Institutet, Institute of
Environmental Medicine, Stockholm, Sweden, and William Slikker Jr.,
US FDA, Jefferson, AR.
Sponsor:
Mechanisms Specialty Section
Endorsed by:
Food Safety Specialty Section
Mechanisms Specialty Section
Neurotoxicology Specialty Section
Ocular Toxicology Specialty Section
Cell death is the ultimate result of toxicity caused by damage to
critical cell functions and/or activation of death signaling pathways.
Toxicants can trigger multiple modes of cell death (apoptosis, necrosis,
necroptosis, and autophagic cell death) with distinct morphological
and biochemical characteristics. In fact, several cell death modalities
may coexist within the same lesion with cross-talk between them. To
address this important topic, we will begin by discussing the role that
cell death plays in toxic insult and disease, and how improved knowledge
of cell death signaling pathways and mechanisms will help us
understand how toxicants might interfere with cell viability and function.
After the description of various cell death modalities, and the
possible cross-talk between them, mechanisms of apoptotic cell death
caused by anesthetics in the developing brain and of lead-induced
apoptosis in retinal photoreceptors will be presented as examples of
cell death caused by toxic insult. These studies illustrate the critical
The Thematic Track information can be found on pages 8–9.
roles of the calcium ion and of reactive oxygen species as mediators of
neurotoxicity, as well as the difference in sensitivity of the mitochondrial
populations in rods and cones to apoptotic stimuli. Thereafter,
the mechanisms of action of certain chemotherapeutic agents and
fungal toxins will be discussed to illustrate the role of sphingolipid
signaling molecules in cell death and disease. Finally, a molecular
epidemiology approach using novel technologies to assess cell death
and environmental impact in individual cells and in human populations
in a high-throughput manner will be presented. The program
will cover important toxicity mechanisms in multiple target organs
and will hopefully contribute to a better understanding of the role of
cell death mechanisms in toxic insult and disease.
• Modes and Pathways of Toxicant-Induced Cell Death.
Boris Zhivotovsky, Karolinska Institutet, Institute of Environmental
Medicine, Stockholm, Sweden.
• Pathways to Anesthetic-Induced Brain Cell Death and to
Neuronal Protection. William Slikker Jr., US FDA, Jefferson, AR.
• Differential Pathways of Cell Death by Lead and Neuroprotection
by Bcl-xL in Photoreceptor Synaptic and Nonsynaptic
Mitochondria. Donald A. Fox, University of Houston, Houston,
TX.
• Ceramide, Sphingoid Bases, and Sphingoid Base Metabolites As
Lipid Mediators in Signaling Pathways Leading to Cell Death and
Disease. Ronald Riley, US Department of Agriculture, Athens, GA.
• Measuring Cell Death and Genotoxicity in Single Cells and
Human Populations Using Lab-on-a-Chip Technologies.
Martyn Smyth, University of California, Berkeley, CA.
Tuesday
An Intelligent Reproductive and Developmental
Testing Paradigm for the 21st Century
Tuesday, March 13, 9:00 AM to 11:45 AM
Chairperson(s): David Dix, US EPA, Research Triangle Park, NC,
and Thomas Knudsen, US EPA, Research Triangle Park, NC.
Sponsor:
Reproductive and Developmental Toxicology Specialty Section
Endorsed by:
In Vitro and Alternative Methods Specialty Section
Regulatory and Safety Evaluation Specialty Section
Risk Assessment Specialty Section
Addressing the chemical evaluation bottleneck that currently exists
can only be achieved through progressive changes to the current
testing paradigm. The primary resources for addressing these issues
lie in computational toxicology, a field enriched by recent advances in
computer science, bio- and chem-informatics, molecular biology, and
high-throughput screening (HTS). In vivo testing is resource inten-
Thematic Session
74
SOT’s 51 st Annual Meeting