51st Annual Meeting & ToxExpo - Society of Toxicology

San Francisco, California
The Thematic Track information can be found on pages 8–9.
• Parallel Animal and Human Research Identify Neurotoxic Effects
of Occupational Exposures to the Organophosphorus Pesticide
Chlorpyrifos. Pamela J. Lein, University of California School of
Veterinary Medicine, Davis, CA.
• Chronic Exposure to the Nerve Agent VX: Physiological,
Behavioral, Histopathological, and Neurochemical Studies.
Eugenia Bloch-Shilderman, Israel Institute for Biological Research,
Ness Ziona, Israel.
• Soman-Induced Brain Damage and Neurological Deficits:
Neuroinflammatory Disorders and Changes in Brain
Metabolism—Consequences for Therapy. Pierre Carpentier,
Institut de Recherche Biomédicale des Armées, La Tronche,
Grenoble, France.
• Temporal, Regional, and Cellular Progression of
Neuroinflammation following Organophosphate Nerve Agent-
Induced Status Epilepticus in Rats. Erik Johnson, US Army
Medical Research Institute of Chemical Defense, Aberdeen Proving
Ground, MD.
• Noncholinergic Mechanisms in the Toxic Effects of
Organophosphate Poisoning—Attempts to Design Effective
Antidotal Counter Measures. Lily Raveh, Israel Institute for
Biological Research, Ness Ziona, Israel.
• Neurotoxicological Effects of Exposure to Organophosphate (OP)
Compounds: The Similarities and Differences between Low and
High Doses. John H. McDonough, US Army Medical Research
Institute of Chemical Defense, Aberdeen Proving Ground, MD.
Influence of Global Climate Change on
Environmental Health Issues
Emerging Mechanistic Targets in Lung Injury
Induced by Combustion-Generated Particles
Thursday, March 15, 9:00 AM to 11:45 AM
Symposia
Environmental combustion-generated air pollutants are a global
concern, and the adverse effects of such materials on human health,
particularly respiratory and cardiovascular health, are firmly established.
Despite strong epidemiological evidence linking ambient air
pollutants to specific human diseases and general health decline, a
significant gap remains in our understanding of precisely how such
materials produce nonneoplastic respiratory diseases. This symposium
will highlight recent advances in our understanding of the
molecular and chemical mechanisms that govern lung and lung cell
toxicity by common respirable forms of complex ambient particulate
materials originating from the combustion of fossil fuels, wood, or
tobacco. Presentations will describe the current understanding of
nonneoplastic respiratory diseases induced by combustion-derived
particulate matter (PM); the participation of transient receptor
potential (TRP) channels in detecting and initiating responses to
unique forms of environmental combustion-derived PM to produce
acute lung inflammation/injury/remodeling; the role of disrupted cell
and mitochondrial iron homeostasis in wood combustion-derived
PM toxicity, and the isolation and chemico-physical characterization
of insoluble nanosized particles from cigarette smoke condensate
including their cytotoxic potential. Attendees of this symposium
session will gain up-to-date knowledge of novel cellular processes and
PM components that appear to regulate the acute toxicological effects
of particulate air pollutants. These effector molecules may represent
important targets for future therapeutic strategies to mitigate the
adverse impact of inhaled combustion-generated pollutants.
• Current Understanding of Nonneoplastic Disease Following
Exposure to Fossil Fuel and Biomass Combustion Emissions.
M. Ian Gilmour, US EPA, Research Triangle Park, NC.
• Differential Activation of TRPA1, V1, and M8 by Combustion-
Derived PM and PM Components: Relationship to Lung
Inflammation and Injury. Christopher Reilly, University of Utah,
Salt Lake City, UT.
• Role of TRPV4-Mediated Calcium Influx in Diesel Exhaust
Particle-Induced Lung Toxicity. Wolfgang Liedtke, Duke
University, Durham, NC.
• Wood Smoke Particles Sequester Mitochondrial Iron Resulting in
Biological Effect. Andrew Ghio, US EPA, Chapel Hill, NC.
• Cytotoxic Insoluble Nanosized Particles in Reference Cigarette
Smoke Condensate. Marc Fariss, Altria Client Services, Richmond,
VA.
Scientific
Chairperson(s): Marc Fariss, Altria Client Services, Richmond, VA,
and Andrew Ghio, US EPA, Chapel Hill, NC.
Sponsor:
Inhalation and Respiratory Specialty Section
Endorsed by:
Mechanisms Specialty Section
Molecular Biology Specialty Section
Occupational and Public Health Specialty Section
up-to-date information at www.toxicology.org 83
Thematic Session