51st Annual Meeting & ToxExpo - Society of Toxicology

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Society of Toxicology 2012 Scientific Symposia Characterizing Toxic Modes of Action and Pathways to Toxicity Realizing the Vision of 21st Century Toxicity Testing: Genetic Approaches to Pathway Analysis Thursday, March 15, 9:00 AM to 11:45 AM Chairperson(s): Chris Corton, US EPA, Research Triangle Park, NC, and Lyle Burgoon, US EPA, Durham, NC. Sponsor: Molecular Biology Specialty Section Endorsed by: In Vitro and Alternative Methods Specialty Section Mechanisms Specialty Section The US National Academy of Science (NAS) report, “Toxicity Testing in the 21st Century,” outlined a vision that virtually all routine toxicity testing would be conducted in human cell lines by evaluating cellular responses of toxicity pathway assays using high-throughput tests. Dose-response modeling of perturbations of pathway function would be organized around computational systems biology models of the circuitry underlying each toxicity pathway. Although there is a growing consensus that this vision will one day become reality, the difficult task of linking changes in the expression or modification of components in pathways to toxicity have yet to be fully realized. There is a clear need to better incorporate new and existing genetic tools that can be routinely used by toxicologists allowing relationships between chemical exposure, genetic networks, and phenotypic responses to be better understood. This symposium brings together experts to discuss genetic analysis of pathways that can be generally applied to toxicology and as such will help move us toward realizing the vision of the NAS report. This important topic will begin with a discussion on global approaches to discover genetic targets of disease, drugs, and environmental chemicals by coupling transcript profiling with GWAS. To expand on this information, widely applicable high-throughput approaches to identify gene, pathway, and phenotypic relationships using small inhibitor RNA arrays will be addressed. Final discussions will discuss genetic approaches in vertebrates to discover biomarkers of pathways and gene-chemical interactions applicable to predicting mode of action of cancer and developmental toxicity. The summary provided will bring together the salient findings in the previous talks to highlight bioinformatic NextGen risk assessment approaches that can assist the toxicologist to enable linkages of chemicals, genes/ pathways, and diseases in chemical risk assessment. This topic will appeal to a wide audience interested in the promising approaches for the analysis and use of pathway perturbations in toxicity testing. • A Reverse Engineering Approach to Constructing Networks of Chemical Response. Eric Schadt, Pacific Biosciences, Menlo Park, CA. The Thematic Track information can be found on pages 8–9. • Expanding the Scope of Loss of Function Genomic Screening with RNAi Cell Microarrays. Juha Rantala, Oregon Health and Science University, Corvallis, OR. • Use of Predictive Markers of Cancer Mode of Action through Integration of Genetics and Genomics. Chris Corton, US EPA, Research Triangle Park, NC. • Rapid In Vivo Assessment of Chemical-Gene Interactions in Embryonic Zebrafish. Robert Tanguay, Oregon State University, Corvallis, OR. • Mashing the Diseaseome, Toxicogenomics, and Frozen Pizzas: Network Systems Biology and Its Impacts on NexGen Risk Assessments. Lyle Burgoon, US EPA, Durham, NC. Thematic Session 84 SOT’s 51 st Annual Meeting
San Francisco SOT 2012 Submit Your Recent Scientific Research during an Extended Abstract Submission Phase The Society is poised to have another successful Annual Meeting with currently close to 2,800 presentations scheduled to be presented in San Francisco, March 11–15, 2012. California We invite you to submit an abstract during the extended submission phase which will occur from December 12, 2011, through January 20, 2012. All abstracts will be submitted online. The cost to submit an abstract is $50. All accepted abstracts will be programmed on Thursday, March 15 along with several dynamic symposia and workshop sessions. Please note the established criteria that qualify an abstract to be accepted during this final submission phase. • The research must be new and of sufficient scientific importance to merit special consideration after the standard abstract deadline. Abstracts should describe highimpact original research that could not be completed prior to the original deadline. • Scientists who had to wait until after the original October deadline to submit due to funding issues are encouraged to submit an abstract for consideration. • Your abstract should not be a revision of a previously-submitted one that was not accepted unless you received specific communication from the Scientific Program Committee suggesting that resubmission during the late abstract period may be appropriate. • Not more than one abstract will be accepted by the same presenting author. • All abstracts will be reviewed by the Scientific Program Committee and held to the same standards used to evaluate abstracts submitted for the original deadline. • Given the Society’s current publishing deadline, the abstracts accepted will be provided as a printed addendum but searchable through the Itinerary Planner (mobile and online versions only). We look forward to welcoming you to the Society’s Annual Meeting in San Francisco, California. up-to-date information at www.toxicology.org 85
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51st Annual Meeting & ToxExpo - Society of Toxicology

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