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CPG for Psychosocial Interventions in Severe Mental ... - GuíaSalud

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Figure 1. Search Strategy<br />

Search <strong>for</strong><br />

<strong>CPG</strong>s <strong>in</strong><br />

GuíaSalud National<br />

Guidel<strong>in</strong>es<br />

Clear<strong>in</strong>ghouse<br />

Trip Database<br />

G-I-N<br />

26 <strong>CPG</strong>s<br />

identifi ed<br />

selected those<br />

that conta<strong>in</strong>ed<br />

psychosocial<br />

<strong>in</strong>terventions<br />

First<br />

selection<br />

5 <strong>CPG</strong>s<br />

selected<br />

Each <strong>CPG</strong><br />

was<br />

Assessed by<br />

4 reviewers<br />

AGREE<br />

Instrument<br />

Cut-off values was<br />

established:<br />

score ><br />

75% <strong>in</strong> area 3<br />

3 <strong>CPG</strong>s<br />

selected<br />

Each one of the 5 <strong>CPG</strong>s selected was assessed by 4 <strong>in</strong>dependent reviewers. The cut-off values<br />

to accept the guidel<strong>in</strong>es was set at 60%, except <strong>for</strong> the methodology section, area 3: rigour<br />

and preparation, where the cut-off had to be over 75%. F<strong>in</strong>ally, only 3 <strong>CPG</strong> passed the established<br />

cut-off value: The <strong>CPG</strong>s on Schizophrenia, Bipolar Disorder and Compulsive Obsessive Disorder<br />

developed by the National Institute <strong>for</strong> Health and Cl<strong>in</strong>ical Excellence of the United K<strong>in</strong>gdom<br />

(NICE) 7,8,9 , and it was decided to use them as a secondary source of evidence that would help<br />

answer some specific aspects.<br />

Once the part correspond<strong>in</strong>g to the identification and analysis of published <strong>CPG</strong>s had ended,<br />

<strong>in</strong> order to make the bibliographic search <strong>for</strong> relevant evidence that might respond to the questions<br />

of the <strong>CPG</strong> <strong>for</strong>mulated previously, it was established that the follow<strong>in</strong>g general databases would<br />

be consulted: Medl<strong>in</strong>e, Cochrane Library, Embase and PsycINFO. Furthermore, different websites,<br />

entities and associations were consulted, such as the Centre <strong>for</strong> Reviews and Dissem<strong>in</strong>ation<br />

(CRD), NICE, American Psychiatric Association (APA), and Cl<strong>in</strong>icaltrIals.gov. Mesh term and<br />

free language were used <strong>for</strong> the search strategy <strong>in</strong> order to improve the sensitivity and specificity<br />

of the search. The search was restricted to systematic reviews of randomised control trials<br />

and orig<strong>in</strong>al studies of randomised and non-randomised control trials and to English, French,<br />

Portuguese and Spanish languages. A hand search was also carried out to review the references of<br />

the identified, <strong>in</strong>cluded or excluded studies. A hand search was carried out <strong>in</strong> scientific magaz<strong>in</strong>es<br />

to obta<strong>in</strong> <strong>in</strong><strong>for</strong>mation on some aspects of the <strong>CPG</strong> .<br />

Due to the lack of quality evidence relat<strong>in</strong>g to some specific aspects of the questions, an extended<br />

search <strong>for</strong> orig<strong>in</strong>al observational studies and case series was carried out, and grey literature<br />

(conferences, unpublished reports, etc.) at national and <strong>in</strong>ternational level, was consulted.<br />

Be<strong>for</strong>e f<strong>in</strong>ish<strong>in</strong>g the <strong>CPG</strong>, a f<strong>in</strong>al search was carried out <strong>for</strong> recently published articles (until<br />

December 2008) that might help answer some of the questions of the <strong>CPG</strong>. It was then critically<br />

26 CLINICAL PRACTICE GUIDELINES IN THE SPANISH NHS

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