CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
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Figure 1. Search Strategy<br />
Search <strong>for</strong><br />
<strong>CPG</strong>s <strong>in</strong><br />
GuíaSalud National<br />
Guidel<strong>in</strong>es<br />
Clear<strong>in</strong>ghouse<br />
Trip Database<br />
G-I-N<br />
26 <strong>CPG</strong>s<br />
identifi ed<br />
selected those<br />
that conta<strong>in</strong>ed<br />
psychosocial<br />
<strong>in</strong>terventions<br />
First<br />
selection<br />
5 <strong>CPG</strong>s<br />
selected<br />
Each <strong>CPG</strong><br />
was<br />
Assessed by<br />
4 reviewers<br />
AGREE<br />
Instrument<br />
Cut-off values was<br />
established:<br />
score ><br />
75% <strong>in</strong> area 3<br />
3 <strong>CPG</strong>s<br />
selected<br />
Each one of the 5 <strong>CPG</strong>s selected was assessed by 4 <strong>in</strong>dependent reviewers. The cut-off values<br />
to accept the guidel<strong>in</strong>es was set at 60%, except <strong>for</strong> the methodology section, area 3: rigour<br />
and preparation, where the cut-off had to be over 75%. F<strong>in</strong>ally, only 3 <strong>CPG</strong> passed the established<br />
cut-off value: The <strong>CPG</strong>s on Schizophrenia, Bipolar Disorder and Compulsive Obsessive Disorder<br />
developed by the National Institute <strong>for</strong> Health and Cl<strong>in</strong>ical Excellence of the United K<strong>in</strong>gdom<br />
(NICE) 7,8,9 , and it was decided to use them as a secondary source of evidence that would help<br />
answer some specific aspects.<br />
Once the part correspond<strong>in</strong>g to the identification and analysis of published <strong>CPG</strong>s had ended,<br />
<strong>in</strong> order to make the bibliographic search <strong>for</strong> relevant evidence that might respond to the questions<br />
of the <strong>CPG</strong> <strong>for</strong>mulated previously, it was established that the follow<strong>in</strong>g general databases would<br />
be consulted: Medl<strong>in</strong>e, Cochrane Library, Embase and PsycINFO. Furthermore, different websites,<br />
entities and associations were consulted, such as the Centre <strong>for</strong> Reviews and Dissem<strong>in</strong>ation<br />
(CRD), NICE, American Psychiatric Association (APA), and Cl<strong>in</strong>icaltrIals.gov. Mesh term and<br />
free language were used <strong>for</strong> the search strategy <strong>in</strong> order to improve the sensitivity and specificity<br />
of the search. The search was restricted to systematic reviews of randomised control trials<br />
and orig<strong>in</strong>al studies of randomised and non-randomised control trials and to English, French,<br />
Portuguese and Spanish languages. A hand search was also carried out to review the references of<br />
the identified, <strong>in</strong>cluded or excluded studies. A hand search was carried out <strong>in</strong> scientific magaz<strong>in</strong>es<br />
to obta<strong>in</strong> <strong>in</strong><strong>for</strong>mation on some aspects of the <strong>CPG</strong> .<br />
Due to the lack of quality evidence relat<strong>in</strong>g to some specific aspects of the questions, an extended<br />
search <strong>for</strong> orig<strong>in</strong>al observational studies and case series was carried out, and grey literature<br />
(conferences, unpublished reports, etc.) at national and <strong>in</strong>ternational level, was consulted.<br />
Be<strong>for</strong>e f<strong>in</strong>ish<strong>in</strong>g the <strong>CPG</strong>, a f<strong>in</strong>al search was carried out <strong>for</strong> recently published articles (until<br />
December 2008) that might help answer some of the questions of the <strong>CPG</strong>. It was then critically<br />
26 CLINICAL PRACTICE GUIDELINES IN THE SPANISH NHS