CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
CPG for Psychosocial Interventions in Severe Mental ... - GuÃaSalud
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Specific symptoms: when CBT was compared with other psychological<br />
treatments, no positive effect was observed <strong>in</strong> the improvement of delirium<br />
(1 RCT, n = 40; WMD = 1.4; 95% CI: between -2.3 and 5.1; proof of the<br />
global effect = 0.74;p = 0.5), but it was found with respect to halluc<strong>in</strong>ations<br />
(1 RCT; n = 40; WMD = 1.24; 95% CI: between 2.1 and 4.6; proof of the<br />
global effect = -0.12; p = 0.9) 42<br />
Cognitive-behavioural therapy (BCT) vs standard treatment (ST)<br />
Relapses<br />
There is not sufficient evidence to determ<strong>in</strong>e if CBT improves relapses when SR (1+)<br />
compared with standard care (rout<strong>in</strong>e care, Case Management and medication)<br />
dur<strong>in</strong>g treatment (n = 121; RR = 0.88, 95% CI: between 0.46 and 1.66),<br />
when compared with standard care 12 months after treatment (n = 61; RR =<br />
1.51; 95% CI: between 0.79 and 2.87) and 1-2 years after treatment (n = 154;<br />
RR = 0.83, 95% CI: between 0.6 and 1.13) 8<br />
Longer-last<strong>in</strong>g CBT programmes (more than 3 months) reduce relapses,<br />
compared with other <strong>in</strong>terventions (n = 177; RR = 0.72, 95% CI: between<br />
0.52 and 0.99; NNT = 7; 95% CI: between 4 and 100) 8<br />
Symptoms<br />
There is certa<strong>in</strong> evidence that <strong>in</strong>dicates that CBT, when compared with ST, SR (1-)<br />
reduces symptoms at the end of the treatment (there is no significant improvement<br />
taken as the reduction of 40% <strong>in</strong> the total score of the BPRS scale<br />
or as the reduction of 50% <strong>in</strong> the positive symptoms of the BPRS scale (n =<br />
121; RR = 0.78; 95% CI: between 0.66 and 0.92; NNT = 5; 95% CI: between<br />
4 and 13) 8<br />
CBT improves the mental state when compared with standard treatment<br />
at the end of the treatment (f<strong>in</strong>al scores of the PANSS/BPRS/CPRS<br />
SR (1+)<br />
scales: n = 580; SMI = -0.21; 95% CI: between -0.38 and -0.04) 8<br />
There is not sufficient evidence that <strong>in</strong>dicates that CBT reduces symptoms<br />
when compared with other psychological <strong>in</strong>terventions at the end of<br />
SR (1-)<br />
the treatment (there is no significant improvement when measured as the<br />
reduction of 50% <strong>in</strong> positive symptoms of the BPRS scale: n = 121; RR =<br />
0.76; 95% CI: between 0.62 and 0.93; NNT = 5; 95% CI between 3 and 15),<br />
nor at 9-12 months after treatment (there is no important improvement, taken<br />
as the reduction of 20% <strong>in</strong> the total score of the BPRS scale or 20% <strong>in</strong> the<br />
reduction of the score of the positive symptoms of the BPRS scale: n = 149;<br />
RR = 0.79; 95% CI: between 0.63 and 1.00) 8<br />
Persistent Symptomatology<br />
It is not possible to determ<strong>in</strong>e if CBT reduces symptoms after 9 months’ SR (1-)<br />
follow-up (there is no important improvement when measured as a 20% reduction<br />
<strong>in</strong> BPRS: n = 60; RR = 0.53; 95% CI: between 0.35 and 0.81; NNT<br />
= 3, 95% CI between: 2 and 6) 8<br />
CLINICAL PRACTICE GUIDELINES FOR PSICHOSOCIAL INTERVENTIONS IN SEVERE MENTAL ILLNESS 43