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To the best of <strong>Newron</strong>’s knowledge, the following shareholders had holdings of more than<br />
3% of the equity capital or voting rights of <strong>Newron</strong> as at December 31, 2011. The number of<br />
shares shown as well as the holding percentages are based on the last disclosure of shareholding<br />
received from the shareholder. Please be aware that since then, the information could have<br />
become outdated because of changes that did not trigger notifications:<br />
Shareholder Note Holding at Dec. 31, 2011<br />
Shares<br />
% of share capital<br />
Great Point Partners 1 660,395 9.1%<br />
3i Group plc 2 539,937 7.4%<br />
NWB Investissements S.p.r.l.* 2 410,900 5.7%<br />
TVM Life Science Ventures VI GmbH & Co. KG 2 274,062 3.8%<br />
Orbimed 3 243,000 3.3%<br />
Aviva Investors 2 235,000 3.2%<br />
1 As per disclosure of shareholding published Jan. 13, 2011<br />
2 No disclosure in 2011<br />
3 As per registration to 2011 EGM<br />
Link to access individual significant shareholders’ reports:<br />
http://www.six-swiss-exchange.com/shares/companies/major_shareholders_de.html<br />
* Indirectly controlled by Apax France VI<br />
726,435 new shares have been subscribed in a transaction announced by the Company as of<br />
April 5, 2012, by Zambon Company S.p.A. (for details, see page 18).<br />
Cross-shareholdings<br />
As of December 31, 2011, there are no cross-shareholdings in excess of 5% of capital or voting<br />
rights with any other company.<br />
Group Structure and Shareholders – <strong>Newron</strong> Annual Report 2011 15