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subcom mittee meetings usually take between half an hour and three hours. The subcommittees<br />

have a predetermined annual agenda to ensure that important reviews take place at the<br />

appro priate time throughout the year and they undergo a periodic self-review to ensure continued<br />

effectiveness.<br />

Members of senior management are regularly attending the Board and subcommittee<br />

meetings to report on areas of the business within their responsibility, to present proposals<br />

for decision and to participate, if requested by the Board, to the discussion prior to a vote<br />

being taken by the Board.<br />

Information and control instruments<br />

The Board ensures that it receives sufficient information from senior management to perform<br />

its supervisory duty and to make decisions that are reserved for the Board. The Board obtains<br />

the information required to perform its duties through several means:<br />

The members of the Board receive on a monthly to bi-monthly basis a comprehensive<br />

manage ment report designed to provide them with an update on business activities in general<br />

and relevant developments with regard to clinical trials and preclinical activities, the collaboration<br />

with licensing partners, as well as on legal, business development and financial matters.<br />

The reports are subject to discussion during the Board meetings, which senior management<br />

regularly attends. With regard to the subcommittees as described below, the CEO is the main<br />

contact to the members of the nomination and compensation committee, while the CFO<br />

takes this function towards the members of the audit committee. Yet, decisions might be taken<br />

by the members of the Board as well as each subcommittee without the attendance of senior<br />

management, but following presentation of facts and discussion with senior management.<br />

Members of the Board and the subcommittees usually do not participate in meetings of<br />

senior management.<br />

Management provides the Board annually with a consolidated financial budget for the<br />

next business year for the parent company and the subsidiaries, and regularly, senior management<br />

presents to the Board strategic considerations for review, discussion and decision.<br />

The Board and the subcommittees closely follow the progress on the major activities, as<br />

presented by management. Analysis of deviations are to be provided and explained in writing<br />

on a monthly to bi-monthly basis, required action will be closely monitored via update phone<br />

calls. Each member of the Board may demand information on any business of <strong>Newron</strong>’s affairs<br />

and may inspect all books, business files and corporate documents.<br />

On a quarterly basis, the Board of Statutory Auditors is updated as well, as required by<br />

Italian law (see below). The permanent observation and control of the Company’s risks is a<br />

management objective. For identified risks, mainly clinical development and financial risks,<br />

a risk assessment is performed. Appropriate actions (including for example the performance<br />

of additional preclinical or clinical studies, fund-raising activities etc.) are defined and executed<br />

to minimize the risk. Management and Board of the Company during the Board meetings<br />

review the identified risks, discuss and decide on the measures and reassess the situation<br />

after an adequate period of time.<br />

24 <strong>Newron</strong> Annual Report 2011

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