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Intervention Principles and Practice Guidelines for - Underage ...

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• Alcohol has toxic effects on the myelination process in adolescents (Medical News Today, 2005).<br />

Myelination helps to stabilize <strong>and</strong> speed brain processes. Disruption of the myelination process<br />

can lead to cognitive deficiencies (Lewohl, Wang, Miles, Zhang, Dodd, & Harris, 2000).<br />

• Alcohol use by adolescents is associated with prefrontal volume abnormalities that studies have<br />

shown to be gender-specific (Medina et al., 2008).<br />

• Ethanol, the active ingredient in alcoholic beverages, affects several neurotransmitter systems.<br />

When it interacts with gamma-aminobutyric acid (GABA) receptors, the chief neurotransmitter<br />

in the vertebrate central nervous system, it can calm anxiety, impair muscle control, <strong>and</strong> delay<br />

reaction time. It also may decrease the transmission of glutamate, which can cloud thinking <strong>and</strong><br />

eventually lead to a coma (Society <strong>for</strong> Neuroscience, 2008).<br />

• Dopamine is released in the brain when an action satisfies a basic need or desire. Chemical<br />

substances provide a shortcut to achieve such rewards. Alcohol can activate the pleasureproducing<br />

chemistry of the brain. With repeated use, however, the brain’s natural capacity to<br />

produce dopamine is reduced. This, in turn, leads to feelings of depression, anger, boredom,<br />

anxiety, <strong>and</strong> frustration (O’Connell, 2009).<br />

• The pharmacological effects of alcohol <strong>and</strong> other chemical substances most immediately<br />

interfere with optimal brain functioning. The continued use of alcohol <strong>and</strong> other drugs over<br />

time may keep youths from advancing to more complex stages of thinking <strong>and</strong> social interaction.<br />

Youth with alcohol use disorders often per<strong>for</strong>m worse on memory tests <strong>and</strong> have diminished<br />

abilities to plan (Bonnie & O’Connell, 2004). Effects of psychoactive substances on the brain<br />

also may include hallucinations, psychotic episodes, changes in sleep patterns, <strong>and</strong> changes in<br />

concentration abilities. In addition, many youth who make the pursuit of alcohol or other drugs<br />

the focal point of their lives may experience malnutrition because of appetite changes or their<br />

inability to af<strong>for</strong>d nourishing food due to the expense of their substance abuse habit. Youths<br />

may also experience damage to their cardiovascular, respiratory, endocrine, <strong>and</strong> reproductive<br />

systems, <strong>and</strong> organs, including the liver <strong>and</strong> kidneys (Macdonald, 1989; Schonberg & Schnoll,<br />

1986).<br />

Alcohol <strong>and</strong> Other Drugs of Abuse<br />

Alcohol is often the first psychoactive substance that adolescents or young adults use. Many,<br />

however, will eventually begin to use other substances. In fact, the younger a person begins using<br />

alcohol, the more likely he or she is to use other drugs (Hingson, Heeren, & Edwards, 2008). Although<br />

many factors can affect whether youth progress to other drugs <strong>and</strong> which ones they choose, a<br />

frequently seen sequence involves alcohol, followed by tobacco, marijuana, <strong>and</strong> then other illicit hard<br />

drugs (Degenhardt et al., 2009; Gfroerer, Wu, & Penne, 2002; Welte & Barnes, 1985). This progression<br />

is yet another reason to be concerned about underage drinking.<br />

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