Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
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Radioactivity (PSL/mm²)<br />
Homogeneity of IS Distribution on DBS cards<br />
800<br />
700<br />
600<br />
500<br />
400<br />
300<br />
200<br />
100<br />
0<br />
Homogenity of <strong>Internal</strong> <strong>Standard</strong> applied as [14C] Spray<br />
Solution <strong>to</strong> DBS<br />
5 10 20 40<br />
Spay Volume [µL/cm²]<br />
Homogenity of Radiolabeled <strong>Standard</strong> applied as Spray Solution <strong>to</strong> DBS<br />
Spray Volume<br />
Radioactivtity<br />
Mean (n=8) S.D. CV<br />
[µL/cm²] [PSL/mm²] [PSL/mm²] [%]<br />
5 184.83 3.45 1.87<br />
10 274.83 7.40 2.69<br />
20 403.55 11.23 2.78<br />
40 664.79 39.23 5.90<br />
Spray pattern analysis for 14 C<br />
Caffeine on Alstrom 226 cards as<br />
function of sprayed volume:<br />
2 cards (8 spots) per volume<br />
Card B7 (5 µL/100 mm², 10000 dpm)<br />
Card B8 (5 µL/100 mm², 10000 dpm)<br />
Card B9 (10 µL/100 mm², 20000 dpm)<br />
Card B10 (10 µL/100 mm², 20000 dpm)<br />
Card B11 (20 µL/100 mm², 40000 dpm)<br />
Card B12 (20 µL/100 mm², 40000 dpm)<br />
Card B13 (40 µL/100 mm², 80000 dpm)<br />
Card B14 (40 µL/100 mm², 80000 dpm)
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