Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
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Homogeneity of IS Distribution on DBS cards<br />
• Cards were spotted with blank whole blood of rats<br />
• [1-Methyl 14 C] Caffeine (mimicking an IS) sprayed on<strong>to</strong> dried blood<br />
spots on cards with the high precision sprayer ATS4 (CAMAG)<br />
• Radioactivity and its distribution were <strong>de</strong>termined by Imaging<br />
• Homogeneity of IS distribution across the blood spot<br />
• Reproducibility between spots<br />
• Effect of the sprayed solution volume (5 – 40 µL) on reproducibility
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