Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
Internal Standard Application to Dried Blood Spots ... - lc-ms.de
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Life Demo of DBS-MS 500<br />
• API QTRAP 2000 available here at FH Nordwestschweiz<br />
– Sensitivity (MRM) not fully optimized, similar <strong>to</strong> API 3000<br />
• DBS-MS 500 interfaced <strong>to</strong> QTRAP yesterday<br />
• Test Compounds: Formoterol, Loratadine, Nortriptyline<br />
• Calibration range 10 – 5000 ng/mL blood<br />
– 15 µL blood spotted, less than 5 days s<strong>to</strong>red at 5 o C<br />
• IS-Mix was spiked parallel <strong>to</strong> analyte mixture in<strong>to</strong> blood<br />
OR<br />
• IS-Mix solution of 1000 ng/mL each was sprayed on<strong>to</strong> blood spot
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