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Model Organisms in Drug Discovery

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182 MECHANISM OF ACTION IN MODEL ORGANISMS<br />

Matthews, D. J. and Kopczynski, J. (2001). Us<strong>in</strong>g model-system genetics for drug-based<br />

target discovery. <strong>Drug</strong> Discov. Today 6, 141–149.<br />

McClung, C. and Hirsh, J. (1999). The trace am<strong>in</strong>e tyram<strong>in</strong>e is essential for sensitization to<br />

coca<strong>in</strong>e <strong>in</strong> Drosophila. Curr. Biol. 9, 853–860.<br />

Micchelli, C. A., Esler, W. P., Kimberly, W. T., Jack, C., Berezovska, O., Kornilova, A.,<br />

Hyman, B. T., et al. (2002). g-Secretase/presenil<strong>in</strong> <strong>in</strong>hibitors for Alzheimer’s disease<br />

phenocopy Notch mutations <strong>in</strong> Drosophila. FASEB J. 1, 1.<br />

Moore, M. S., DeZazzo, J., Luk, A. Y., Tully, T., S<strong>in</strong>gh, C. M. and Heberle<strong>in</strong>, U. (1998).<br />

Ethanol <strong>in</strong>toxication <strong>in</strong> Drosophila: genetic and pharmacological evidence for regulation<br />

by the cAMP signal<strong>in</strong>g pathway. Cell 93, 997–1007.<br />

Muda, M., Worby, C. A., Simonson-Leff, N., Clemens, J. C. and Dixon, J. E. (2002). Use<br />

of double-stranded RNA-mediated <strong>in</strong>terference to determ<strong>in</strong>e the substrates of prote<strong>in</strong><br />

tyros<strong>in</strong>e k<strong>in</strong>ases and phosphatases. Biochem. J. 366, 73–77.<br />

O’Moore-Sullivan, T. M. and Pr<strong>in</strong>s, J. B. (2002). Thiazolid<strong>in</strong>ediones and type 2 diabetes:<br />

new drugs for an old disease. Med. J. Aust. 176, 381–386.<br />

Parada, L. F., Tab<strong>in</strong>, C. J., Shih, C. and We<strong>in</strong>berg, R. A. (1982). Human EJ bladder<br />

carc<strong>in</strong>oma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297, 474–<br />

478.<br />

Peyroche, A., Antonny, B., Rob<strong>in</strong>eau, S., Acker, J., Cherfils, J. and Jackson, C. L. (1999).<br />

Brefeld<strong>in</strong> A acts to stabilize an abortive ARF-GDP-Sec7 doma<strong>in</strong> prote<strong>in</strong> complex:<br />

<strong>in</strong>volvement of specific residues of the Sec7 doma<strong>in</strong>. Mol. Cell 3, 275–285.<br />

Ramet, M., Manfruelli, P., Pearson, A., Mathey-Prevot, B. and Ezekowitz, R. A. (2002).<br />

Functional genomic analysis of phagocytosis and identification of a Drosophila receptor<br />

for E. coli. Nature 416, 644–648.<br />

Reiter, L. T., Potocki, L., Chien, S., Gribskov, M. and Bier, E. (2001). A systematic<br />

analysis of human disease-associated gene sequences <strong>in</strong> Drosophila melanogaster. Genome<br />

Res. 11, 1114–1125.<br />

Sakowicz, R., Berdelis, M. S., Ray, K., Blackburn, C. L., Hopmann, C., Faulkner, D. J.<br />

and Goldste<strong>in</strong>, L. S. (1998). A mar<strong>in</strong>e natural product <strong>in</strong>hibitor of k<strong>in</strong>es<strong>in</strong> motors.<br />

Science 280, 292–295.<br />

Scussa, F. (2002). World’s best-sell<strong>in</strong>g drugs. Med. Ad. News 21, 1–46.<br />

Shaw, P. J., Cirelli, C. Greenspan, R. J. and Tononi, G. (2000). Correlates of sleep and<br />

wak<strong>in</strong>g <strong>in</strong> Drosophila melanogaster. Science 287, 1834–1837.<br />

Shellenbarger, D. L. and Mohler, J. D. (1978). Temperature-sensitive periods and<br />

autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal <strong>in</strong> Drosophila. Dev.<br />

Biol. 62, 432–446.<br />

Sherr<strong>in</strong>gton, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi,<br />

H., et al. (1995). Clon<strong>in</strong>g of a gene bear<strong>in</strong>g missense mutations <strong>in</strong> early-onset familial<br />

Alzheimer’s disease. Nature 375, 754–760.<br />

Silverman, N. and Maniatis, T. (2001). NF-kappaB signal<strong>in</strong>g pathways <strong>in</strong> mammalian and<br />

<strong>in</strong>sect <strong>in</strong>nate immunity. Genes Dev. 15, 2321–2342.<br />

Silverman, N., Zhou, R., Stoven, S., Pandey, N., Hultmark, D. and Maniatis, T. (2000). A<br />

Drosophila IkappaB k<strong>in</strong>ase complex required for Relish cleavage and antibacterial<br />

immunity. Genes Dev. 14, 2461–2471.<br />

Simon, M. A. (2000). Receptor tyros<strong>in</strong>e k<strong>in</strong>ases: specific outcomes from general signals.<br />

Cell 103, 13–15.<br />

Simon, M. A., Bowtell, D. D., Dodson, G. S., Laverty, T. R. and Rub<strong>in</strong>, G. M. (1991).<br />

Ras1 and a putative guan<strong>in</strong>e nucleotide exchange factor perform crucial steps <strong>in</strong><br />

signal<strong>in</strong>g by the sevenless prote<strong>in</strong> tyros<strong>in</strong>e k<strong>in</strong>ase. Cell 67, 701–716.

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