Model Organisms in Drug Discovery

280 INDEX
bupropion 92
busulfan 143
bystander genes 53
C-C chemokine receptor 2 (CCR2) 263
c-cbl 53
CA-repeats 195, 196
Cactus 172, 173
Caenorhabditis elegans 5, 41–79
assay design 64–6
assay development 66–8
assay validation 69
BMS AG6B 163, 165
conservation 43, 44–5, 50
depression 48–50
disease model 50, 51
drinking assay 52, 56, 66–7, 69, 71
drug discovery 42–5, 72–3
electrophysiology 65–6
expression profiling 58–9, 175
functional assay 50, 52
gene expression topomap 58–9
gene knock-outs 57–8
gene mapping using SNPs 55–6
genetic screens 52–3, 252
genome annotation 60
genomics 43–4
high-throughput screening 64
hits 70–2, 73
image acquisition 67–8
lead discovery 61–73
mechanism of action studies 53–5,
156–9, 161–2
protein interaction mapping 59
RNAi 56–7, 170–1
screening platform 69–70
serotonin signaling 48–9, 50
target identification 60–1
target validation 45–7, 60–1
yeast homologs 12
caffeine 157, 158
calcineurin 16
calcineurin A 264, 265
calmodulin 31
calnexin 1 18
camptothecin 14, 155
cancer 157–9, 143
arachidonic acid 214
insulin pathway 127
lipid metabolism 204
p53 139
Ras pathway 124–6, 158–9
WNT pathway 122–3, 135
see also anticancer drugs
capsaicin 158
carbachol 158
cardiology 262–3
caspases 13
cataracts 238
b-catenin 122
cathepsin K 253
cdk4-specific antagonists 13
cDNA microarrays 58, 175
cdp2 261
Cecropins 172, 173
cell-based assays 94–5
cell culture, Drosophila 109
cell cycle 29
cell growth inhibition 144
cell proliferation 271
Cellzome 31
central nervous system 45
chemical descriptors 63
chemical genetics 6, 53–4, 98, 141–5,
170–2
chemical modifier screen 96–7
chemical mutagens 103, 128, 129–30, 188,
228–35
chico 127
chitinase assay 67
Chk1 20
cholesterol 13, 204, 208, 209–10, 263
circadian rhythms 94, 242, 269
cleavage-based assay 110
CLN3 12
clock 242, 243
CNK 126
cocaine 94, 158
coding regions 11
cognition 270
colon cancer 122
combinatorial chemistry 63
compactin 158
complete blood cell count 264–5
compound
development 154–6
learning set 69
library 63–4
screens 94–8
compound E 169
Comprehensive Yeast Genome Database 32
computer-assisted tomography 256
congestive heart failure 55
conservation 12–13, 43, 44–5, 50, 82–5,
119–27, 186–7, 216
contractile proteins 205
COPAS TM 68
corticotropin-releasing hormones 48
COX inhibitors 156, 214, 216
COX-1 and COX-2 212, 214–17, 268