Model Organisms in Drug Discovery

REFERENCES 275
Bueno, O. F., Brandt, E. B., Rothenberg, M. E. and Molkentin, J. D. (2002). Defective T
cell development and function in calcineurin A beta-deficient mice. Proc. Natl. Acad. Sci.
USA 99, 9398–9403.
Butler, A. A., Kesterson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., et al.,
(2000). A unique metabolic syndrome causes obesity in the melanocortin-3 receptordeficient
mouse. Endocrinology 141, 3518–3521.
Chalfie, M., Horvitz, H. R. and Sulston, J. E. (1981). Mutations that lead to reiterations in
the cell lineages of C elegans. Cell 24, 59–69.
Chen, J. N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F. J.,
Furutani-Seiki, M., et al. (1996). Mutations affecting the cardiovascular system and
other internal organs in zebrafish. Development 123, 293–302.
Clement, S., Krause, U., Desmedt, F., Tanti, J. F., Behrends, J., Pesesse, X., Sasaki, T.,
et al. (2001). The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409, 92–97.
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M. and Caron, M. G. (1996).
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the
dopamine transporter. Nature 379, 606–612.
Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S.,
et al. (2002). Insertional mutagenesis in zebrafish rapidly identifies genes essential for
early vertebrate development. Nat. Genet. 31, 135–140.
Granato, M., van Eeden, F. J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M.,
Haffter, P., et al. (1996). Genes controlling and mediating locomotion behavior of the
zebrafish embryo and larva. Development 123, 399–413.
Haffter, P., Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A.,
Odenthal, J., et al. (1996). The identification of genes with unique and essential functions
in the development of the zebrafish, Danio rerio. Development 123, 1–36.
Hawes, N. L., Smith, R. S., Chang, B., Davisson, M., Heckenlively, J. R. and John, S. W.
(1999). Mouse fundus photography and angiography: a catalogue of normal and mutant
phenotypes. Mol. Vis. 5, 22.
Hedgecock, E. M., Sulston, J. E. and Thomson, J. N. (1983). Mutations affecting
programmed cell deaths in the nematode Caenorhabditis elegans. Science 220, 1277–1279.
Hirose, F., Ohshima, N., Shiraki, M., Inoue, Y. H., Taguchi, O., Nishi, Y., Matsukage, A.,
et al. (2001). Ectopic expression of DREF induces DNA synthesis, apoptosis, and
unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with
Polycomb and trithorax group proteins. Mol. Cell Biol. 21, 7231–7242.
Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A.,
Harrison, N. L., Krasowski, M. D., et al. (1997). Mice devoid of gamma-aminobutyrate
type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
Proc. Natl. Acad. Sci. USA 94, 4143–4148.
Hopkins, A. L. and Groom, C. R. (2002). The druggable genome. Nat. Rev. Drug Discov. 1,
727–730.
Horvitz, H. R. and Sulston, J. E. (1980). Isolation and genetic characterization of celllineage
mutants of the nematode Caenorhabditis elegans. Genetics 96, 435–454.
Ito, M., Oliverio, M. I., Mannon, P. J., Best, C. F., Maeda, N., Smithies, O. and Coffman,
T. M. (1995). Regulation of blood pressure by the type 1A angiotensin II receptor gene.
Proc. Natl. Acad. Sci. USA 92, 3521–3525.
Joshi, R. L., Lamothe, B., Cordonnier, N., Mesbah, K., Monthioux, E., Jami, J. and
Bucchini, D. (1996). Targeted disruption of the insulin receptor gene in the mouse results
in neonatal lethality. EMBO J. 15, 1542–1547.