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Model Organisms in Drug Discovery M
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Copyright u 2003 John Wiley & Sons
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Contents List of contributors .....
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CONTENTS ix 7 Genetics and Genomics
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List of Contributors Hector Beltran
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LIST OF CONTRIBUTORS xiii Stefan Sc
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1 Introduction to Model Systems in
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Organism INTEGRATING MODEL ORGANISM
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INTEGRATING MODEL ORGANISM RESEARCH
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INTEGRATING MODEL ORGANISM RESEARCH
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10 GROWING YEAST FOR FUN AND PROFIT
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12 GROWING YEAST FOR FUN AND PROFIT
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30 GROWING YEAST FOR FUN AND PROFIT
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34 GROWING YEAST FOR FUN AND PROFIT
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36 GROWING YEAST FOR FUN AND PROFIT
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38 GROWING YEAST FOR FUN AND PROFIT
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3 Caenorhabditis elegans Functional
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THE DRUG DISCOVERY PROCESS 43 thoug
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multivulva phenotype of Ras gain-of
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disease. These molecular targets ar
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FROM DISEASE TO TARGET 49 Figure 3.
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FROM DISEASE TO TARGET 51 Figure 3.
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signaling pathway. The third catego
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FROM DISEASE TO TARGET 55 resistant
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phenomenon was first observed in C.
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profiles. The C. elegans gene expre
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emerging technologies. Forward gene
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The compound library LEAD DISCOVERY
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LEAD DISCOVERY 65 previous section,
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LEAD DISCOVERY 67 Figure 3.5 Distri
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Compound learning set for assay val
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10 000-15 000 human drug targets ar
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transporter itself. The SSRIs that
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REFERENCES 75 de Montigny, C., Blie
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REFERENCES 77 Lewis, J. A., Wu, C.
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REFERENCES 79 Tissenbaum, H. A. and
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82 DROSOPHILA AS A TOOL FOR DRUG DI
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84 DROSOPHILA AS A TOOL FOR DRUG DI
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86 DROSOPHILA AS A TOOL FOR DRUG DI
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88 DROSOPHILA AS A TOOL FOR DRUG DI
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90 DROSOPHILA AS A TOOL FOR DRUG DI
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92 DROSOPHILA AS A TOOL FOR DRUG DI
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94 DROSOPHILA AS A TOOL FOR DRUG DI
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96 DROSOPHILA AS A TOOL FOR DRUG DI
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98 DROSOPHILA AS A TOOL FOR DRUG DI
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100 DROSOPHILA AS A TOOL FOR DRUG D
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102 DROSOPHILA AS A TOOL FOR DRUG D
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104 DROSOPHILA AS A TOOL FOR DRUG D
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106 DROSOPHILA AS A TOOL FOR DRUG D
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108 DROSOPHILA AS A TOOL FOR DRUG D
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110 DROSOPHILA AS A TOOL FOR DRUG D
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112 DROSOPHILA AS A TOOL FOR DRUG D
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114 DROSOPHILA AS A TOOL FOR DRUG D
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116 DROSOPHILA AS A TOOL FOR DRUG D
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5 Drosophila - a Model System for T
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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CHEMICAL GENETICS 143 acid identity
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3. A hit identifies a biologically
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about their function in a multicell
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REFERENCES 149 Han, Z. S., Enslen,
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REFERENCES 151 Rintelen, F., Stocke
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6 Mechanism of Action in Model Orga
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INTRODUCTION TO COMPOUND DEVELOPMEN
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MODEL ORGANISMS ARRIVE ON THE SCENE
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ELUCIDATING THE MECHANISM OF COMPOU
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ELUCIDATING THE MECHANISM OF COMPOU
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A CASE STUDY FOR ALZHEIMER’S DISE
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A CASE STUDY FOR ALZHEIMER’S DISE
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272 SATURATION SCREENING OF DRUGGAB
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274 SATURATION SCREENING OF DRUGGAB
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276 SATURATION SCREENING OF DRUGGAB
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278 SATURATION SCREENING OF DRUGGAB
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280 INDEX bupropion 92 busulfan 143
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282 INDEX Dscam 171 dual-energy X-r
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284 INDEX L-685,818 16 lead discove
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286 INDEX protein function 19-22 pr
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288 INDEX yeast (continued) functio