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- Page 1 and 2: Model Organisms in Drug Discovery M
- Page 3 and 4: Copyright u 2003 John Wiley & Sons
- Page 5 and 6: Contents List of contributors .....
- Page 7 and 8: CONTENTS ix 7 Genetics and Genomics
- Page 9 and 10: List of Contributors Hector Beltran
- Page 11 and 12: LIST OF CONTRIBUTORS xiii Stefan Sc
- Page 13 and 14: 1 Introduction to Model Systems in
- Page 15 and 16: Organism INTEGRATING MODEL ORGANISM
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- Page 51 and 52: 3 Caenorhabditis elegans Functional
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- Page 55 and 56: multivulva phenotype of Ras gain-of
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- Page 63 and 64: signaling pathway. The third catego
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88 DROSOPHILA AS A TOOL FOR DRUG DI
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92 DROSOPHILA AS A TOOL FOR DRUG DI
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94 DROSOPHILA AS A TOOL FOR DRUG DI
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96 DROSOPHILA AS A TOOL FOR DRUG DI
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114 DROSOPHILA AS A TOOL FOR DRUG D
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116 DROSOPHILA AS A TOOL FOR DRUG D
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5 Drosophila - a Model System for T
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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EVOLUTIONARY CONSERVATION OF DISEAS
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TARGET IDENTIFICATION/TARGET VALIDA
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TARGET IDENTIFICATION/TARGET VALIDA
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CHEMICAL GENETICS 143 acid identity
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3. A hit identifies a biologically
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about their function in a multicell
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REFERENCES 149 Han, Z. S., Enslen,
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REFERENCES 151 Rintelen, F., Stocke
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6 Mechanism of Action in Model Orga
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INTRODUCTION TO COMPOUND DEVELOPMEN
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MODEL ORGANISMS ARRIVE ON THE SCENE
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ELUCIDATING THE MECHANISM OF COMPOU
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ELUCIDATING THE MECHANISM OF COMPOU
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A CASE STUDY FOR ALZHEIMER’S DISE
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A CASE STUDY FOR ALZHEIMER’S DISE
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A CASE STUDY FOR ALZHEIMER’S DISE
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NEW CHEMICAL GENETIC STRATEGIES 171
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A CASE STUDY FOR INNATE IMMUNITY 17
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GLOBAL GENE EXPRESSION STUDIES IN M
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As described above, the extensive i
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REFERENCES 179 Austin, J. and Kimbl
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REFERENCES 181 Hughes, T. R., Marto
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REFERENCES 183 Sin, N., Meng, L., W
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186 GENETICS AND GENOMICS IN THE ZE
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188 GENETICS AND GENOMICS IN THE ZE
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198 GENETICS AND GENOMICS IN THE ZE
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200 GENETICS AND GENOMICS IN THE ZE
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8 Lipid Metabolism and Signaling in
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FISH AS A MODEL ORGANISM 205 genes
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LIPID METABOLISM SCREEN 207 transpo
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LIPID METABOLISM SCREEN 209 Figure
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the embryo media containing radioac
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ZEBRAFISH AS A MODEL SYSTEM 213 Fig
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ZEBRAFISH AS A MODEL SYSTEM 215 Reg
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aspirin, which has potent inhibitor
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REFERENCES 219 Chau, I. and Cunning
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REFERENCES 221 Patrono, C., Patrign
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224 CHEMICAL MUTAGENESIS IN THE MOU
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226 CHEMICAL MUTAGENESIS IN THE MOU
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228 CHEMICAL MUTAGENESIS IN THE MOU
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238 CHEMICAL MUTAGENESIS IN THE MOU
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240 CHEMICAL MUTAGENESIS IN THE MOU
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242 CHEMICAL MUTAGENESIS IN THE MOU
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244 CHEMICAL MUTAGENESIS IN THE MOU
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246 CHEMICAL MUTAGENESIS IN THE MOU
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248 CHEMICAL MUTAGENESIS IN THE MOU
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250 CHEMICAL MUTAGENESIS IN THE MOU
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252 SATURATION SCREENING OF DRUGGAB
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254 SATURATION SCREENING OF DRUGGAB
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256 SATURATION SCREENING OF DRUGGAB
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276 SATURATION SCREENING OF DRUGGAB
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278 SATURATION SCREENING OF DRUGGAB
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280 INDEX bupropion 92 busulfan 143
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282 INDEX Dscam 171 dual-energy X-r
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284 INDEX L-685,818 16 lead discove
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286 INDEX protein function 19-22 pr
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288 INDEX yeast (continued) functio