Biophysical studies of membrane proteins/peptides. Interaction with ...

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BIBLIOGRAPHY Glaubitz, C., Grobner, G., Watts, A. (2000). Structural and Orientational Information of the Membrane Embedded M13 Coat Protein by 13C-MAS NMR Spectroscopy. Biochim. Biophys. Acta 1463: 151-161. Gokhale, N. A., Abraham, A., Digman, M. A., Gratton, E., and Cho, W. (2005). Phosphoinositide Specificity of and Mechanism of Lipid Domain Formation by Annexin A2-p11 Heterotetramer. J. Biol. Chem. 280: 42831-42840. Grabe, M., Wang, H., and Oster, G. (2000). The Mechanochemistry of V-ATPase Proton Pumps. Biophys. J. 78: 2798-2813. Harrison, M. A., Finbow M. E., and Findlay, J. B. (1997) Postulate for the Molecular Mechanism of the Vacuolar H(+)-ATPase (Hypothesis). Mol. Membr. Biol. 14: 1-3. Harrison, M. A., Murray, J., Powell, B., Kim, Y.-I., Finbow, M. E., and Findlay, J. B. C. (1999). Helical Interactions and Membrane Disposition of the 16-kDa Proteolipid Subunit of the Vacuolar H + -ATPase Analyzed by Cysteine Replacement Mutagenesis. J. Biol. Chem. 274: 25461-25470. Harrison, M., Powell, B., Finbow, M. E., and Findlay, J. B. C. (2000). Identification of Lipid-Acessible Sites on the Nephrops 16-kDa Proteolipid Incorporated into a Hybrid Vacuolar H + -ATPase: Site Directed Labeling with N-(1-Pyrenyl)cyclohexylcarbodiimide and Fluorescence Quenching Analysis. Biochemistry 39: 7531-7537. Hardt, S. L. (1979). Rates of Diffusion Controlled Reactions in One, Two, Three Dimensions. Biophys. Chem. 10: 239-243. Harroun, T. A., Heller, W. T., Weiss, T. M., Yang, L., and Huang, H. W. (1999). Experimental Evidence for Hydrophobic Matching and Membrane-Mediated Interactions in Lipid Bilayers Containing Gramicidin. Biophys. J. 76: 937-945. Harzer, U. and Bechinger, B. (2000). Alignment of Lysine-Anchored Membrane Peptides Under Conditions of Hydrophobic Mismatch: a CD, 15N and 31P Solid-State NMR Spectroscopy Investigation. Biochemistry 39: 13106-13114. Hemminga, M. A., Sanders, J. C., and Spruijt, R. B. (1992). Spectroscopy of Lipid-Protein Interactions: Structural Aspects of Two Different Forms of the Coat Protein of Bacteriophage M13 Incorporated in Model Membranes. Prog. Lipid. Res. 31: 301-333. Henry, G. D., and Sykes, B. D. (1992). Assignment of Amide 1 H and 15 N NMR Resonances in Detergent- Solubilized M13 Coat Protein: A Model for the Coat Protein Dimer. Biochemistry 31: 5284-5297. Hinderliter, A., Almeida, P. F. F., Creutz, C. E., and Biltonen, R. L. (2001). Domain Formation in a Fluid Mixed Lipid Bilayer Modulated Through Binding of the C2 Protein Motif. Biochemistry 40: 4181-4191. 195
Hinderliter, A., Biltonen, R. L., and Almeida, P. F. F. (2004). Lipid Modulation of Protein-Induced Membrane Domains as a Mechanism for Controlling Signal Transduction. Biochemistry 43: 7102-7110. Hooper, D. C., and Wolfson, J. S. (Eds.), (1995). Quinolone Antimicrobial Agents, 2 nd Ed. American Society from Microbiology, Washington D.C, U.S.A. Houston, S., and Farming, A. (1994). Current and Potential Treatment of Tuberculosis. Drugs 48: 689- 708. Ipsen, J. H., Karlstrom, G., Mouritsen, O. G., Wennerstrom, H., and Zuckermann, M. J. (1987). Phase Equilibria in the Phosphatidylcholine-Cholesterol System. Biochem. Biophys. Acta 905:162–72. Jensen, M. O, and Mouritsen, O. G. (2004). Lipids do Influence Protein Function – The Hydrophobic Matching Hypothesis Revisited. Biochim. Biophys. Acta 1666: 205-226. Jorgensen, K., and Mouritsen, O. G. (1995). Phase Separation Dynamics and Lateral Organization of Two-Component Lipid Membranes. Biophys. J. 95: 942-954. Kawasaki-Nishi, S. Nishi, T., and Forgac, M. (2003). Proton Translocation Driven by ATP Hydrolisis in V-ATPases. FEBS Letters 545: 76-85. Killian, J. A., Trouard, T. P., Greathouse, D. V., Chupin, V., Lindblom, G. (1994). A General Method for the Preparation of Mixed Micelles of Hydrophobic Peptides and Sodium Dodecyl Sulphate. FEBS Lett. 348: 161-165. Killian, J. A. (2003). Synthetic Peptides as Models for Intrinsic Membrane Proteins. FEBS Lett. 555: 134-138. Kitamura, A., Kiyota, T., Tomohiro, M., Umeda, A., Lee, S., Inoue, T., and Sugihara, G. (1999). Morphological Behaviour of Acidic and Neutral Liposomes Induced by Basic Amphiphilic Alpha-Helical Peptides with Systematically Varied Hydrophobic-Hydrophilic Balance. Biophys. J. 76: 1457-1468. Kuhn, A., Wickner, W., and Kreil, G. (1986). The Cytoplasmic Carboxy Terminus of M13 Procoat is Required for the Membrane insertion of its Central Domain. Nature 322: 335-339. Klausner, R. D., and Wolf, D. E. (1980). Selectivity of Fluorescent Lipid Analogues for Lipid Domains. Biochemistry 19: 6199-6203. Knol, J., Sjollema, K., and Poolman, B. (1998). Detergent-Mediated Reconstitution of Membrane Proteins. Biochemistry 37: 16410-16415. Korlach, J., Schwille, P., Webb, W.W., Feigenson, G.W. (1999). Characterization of Lipid Bilayer Phases by Confocal Microscopy and Fluorescence Correlation Spectroscopy. Proc. Natl. Acad. Sci. U.S.A. 96: 8461-8466. 196
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UNIVERSIDADE TÉCNICA DE LISBOA INS
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Fernandes, F., Loura, L. M. S., Fed
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Ao Pedro e Hugo, amigos de longa da
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2.2. - Peptides as models 2.3. - Am
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ABBREVIATIONS AND SYMBOL LIST ABBRE
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RESUMO RESUMO As biomembranas são
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SINOPSE SINOPSE Nas últimas duas d
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SINOPSE podem fornecer informação
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SINOPSE aceitantes. Dadores mais pr
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OUTLINE OUTLINE The last two decade
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OUTLINE membranes with a distributi
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OUTLINE BAR domains (tubulation of
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ion diffusion, as the energy requir
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acid. If no more groups are linked
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sphingomyelin, the most abundant sp
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signal for neighbouring cells to ph
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functional role in process such as
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in the L α phase, while lateral di
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1.7. Lateral heterogeneity in lipid
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the vesicle through bilayer deforma
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Figure I.9 - Depiction of the sever
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Figure I.11 - Experimentally obtain
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drying into a film and ressuspensio
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deactivating agents. Zwitterionic d
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amphipatic helices (see Section 2.3
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size corresponding to the hydrophob
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changes abruptly in the interfacial
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thickness of the bilayer (Section 1
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some α-helical membrane proteins a
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The formation of a lipid population
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homogeneous distribution of lipids
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Figure I.20 - Relative binding cons
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2.9. Lipid phase preferential parti
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In Figure I.21, theoretical simulat
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PROTEIN-PROTEIN AND PROTEIN-LIPID I
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2430 Biophysical Journal Volume 85
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2432 Fernandes et al. Coat protein
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2434 Fernandes et al. leads to an a
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2436 Fernandes et al. FIGURE 4 (A)
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2438 Fernandes et al. section of th
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2440 Fernandes et al. tein oligomer
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QUANTIFICATION OF PROTEIN-LIPID SEL
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FRET Study of Protein-Lipid Selecti
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BINDING OF INHIBITORS TO A PUTATIVE
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BINDING OF INHIBITORS TO A PUTATIVE
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INTERACTION OF THE INDOLE CLASS OF
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5272 Biochemistry, Vol. 45, No. 16,
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BINDING ASSAYS OF INHIBITORS TOWARD
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1778 F. Fernandes et al. / Biochimi
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apparently the most significant as
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110
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Introduction Quinolones are broad-s
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[9-12]. Having this into considerat
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any case, very similar, probably wi
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placement of the protein around the
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⎛ II t ⎛ R ⎞ 0 ρ () t = exp
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APPENDIX - Derivation of the FRET r
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2 2w J ( t) = '2 R − R + w / 1
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[14] L. Plançon, M. Chami, L. Lete
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acceptors) (Eqs. 4-6) (⋅-⋅-⋅)
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FIGURE 1A FIGURE 1B 130
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136
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dynamin. Soon after, the same group
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140
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Page 172 and 173: Introduction Control of membrane re
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Page 184 and 185: Figure Legends Fig.1: N-terminal am
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Page 196 and 197: The signalling functions of PI(4,5)
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Page 202 and 203: zoxadiazol (NBD)-PC were obtained f
Page 204 and 205: Fig. 3. Fluorescence decays of diph
Page 206 and 207: CONCLUSIONS VII CONCLUSIONS Chapter
Page 208 and 209: CONCLUSIONS constants recovered by
Page 210 and 211: CONCLUSIONS Chapter IV ‐ Binding
Page 212 and 213: CONCLUSIONS Chapter VI - Clustering
Page 214 and 215: FINAL CONSIDERATIONS AND PROSPECTS
Page 216 and 217: BIBLIOGRAPHY IX BIBLIOGRAPHY Albert
Page 218 and 219: BIBLIOGRAPHY Phosphatidylinositol 4
Page 222 and 223: BIBLIOGRAPHY Koehorst, R. B. M., Sp
Page 224 and 225: BIBLIOGRAPHY Mishra, V. K., Palguna
Page 226 and 227: BIBLIOGRAPHY Pluschke, G., Hirota,
Page 228 and 229: BIBLIOGRAPHY Sperotto, M. M., and M
Page 230: BIBLIOGRAPHY Williamson, I. M., Alv
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