Biophysical studies of membrane proteins/peptides. Interaction with ...

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BIBLIOGRAPHY Koehorst, R. B. M., Spruijt, R. B., Vergeldt, F. J. and Hemminga, M. A. (2004). Lipid Bilayer Topology of the Transmembrane α-Helix of M13 Major Coat Protein and Bilayer Polarity Profile by Site-Directed Fluorescence Spectroscopy. Biophys. J. 87: 1445-1455. Kwik, J., Boyle, S., Fooksman, Margolis, L., Sheetz, M. P., and Edidin, M. (2003). Membrane Cholesterol, Lateral Mobility, and the Phosphatidylinositol 4,5-Bisphosphate-Dependent Organization of Cell Actin. PNAS USA. 100: 13964-13969. Lark, M. W., James, I. E. (2002). Novel Bone Antiresorptive Approaches. Curr. Opin. Pharmac. 2: 330- 337. Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., and Caroni, P. (2000). GAP43, MARCKS, and CAP23 Modulate PI(4,5)P 2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics Through a Common Mechanism. J. Cell Biol. 149: 1455-1471. Lee, A.G. (2003). Lipid-Protein Interactions in Biological Membranes: a Structural Perspective. Biophys. Biochim. Acta 1612: 1-40. Lehtonen, J. Y. A., Holopainen, J. M., and Kinnunen, P. K. (1996). Evidence for the Formation of Microdomains in Liquid Crystalline Large Unilamellar Vesicles Caused by Hydrophobic Mismatch of the Constituent Phospholipids. Biophys. J. 70: 1753-1760. Lehtonen, J. Y. A., and Kinnunen, P. K. J. (1997). Evidence for Phospholipid Microdomain Formation in Liquid Crystalline Liposomes Reconstituted With Eschericia coli Lactose Permease. Biophys. J. 72: 1247-1257. Liu, F., Lewis, R. N. A. H., Hodges, R. S., and McElhaney, R. N. (2002). Effect of Variations in the Structure of a Polyleucine-Based α-Helical Transmembrane Peptide on its Interactions with Phosphatidylcholine Bilayers. Biochemistry 87: 2470-82 Lentz, B. R., Barenholz, Y. and Thompson, T. E. (1976). Fluorescence Depolarization Studies of Phase Transitions and Fluidity in Phospholipid Bilayers. 2. Two-component Phosphatidylcholine Liposomes. Biochemistry 15:4529–4537. Lentz, T. L., Chaturverdi, V., and Conti-Fine, B. M. (1998). Amino Acids Within Residues 181-200 of the Nicotinic Acetylcholine Receptor Alpha1 Subunit Involved in Nicotine Binding. Biochem. Pharmacol. 55: 341-347. Lewis, B. A., and Engelman, D. M. (1983). Bacteriorhodopsin Remains Dispersed in Fluid Phospholipid Bilayers Over a Wide Range of Bilayer Thickness. J. Mol. Biol. 166:203–210. Liu, Y., Casey, L., and Pike, L. J. (1998). Compartmentalization of Phosphatidylinositol 4,5- Bisphosphate in Low-Density Membrane Domains in the Absence of Caveolin. Biochem. Biophys. Res. Commun. 245: 684-690. 197
Lodish, H., Berk, A., Zipursky, S. L., Matsudaira, P., Baltimore, D., and Darnell, J. E. (2000). Molecular Cell Biology. 4 th Ed. W. H. Freeman, New York, USA Mall, S., Broadbridge, R., Sharma, R. P., Lee, A. G., and East J. M. (2000). Effects of Aromatic Residues at the Ends of Transmembrane Alpha-Helices on Helix Interactions With Bilayers. 39: 2071-2078. Mall, S., East, J. M., and Lee, A. G. (2002). Transmembrane α-Helices. in Current Topics in Membranes 52: 339-371 Marsh, D. (1990). Lipid-Protein Interactions in Membranes. FEBS Lett. 268: 271-375. Marsh, D. (1996). Peptide Models for Membrane Channels. Biochem, J. 315: 345-361. Marsh, D., Horváth, L. I., Swamy, M. J., Mantripragada, S., and Kleinschmidt, J. H. (2002). Interactions of Membrane-Spanning Proteins With Peripheral and Lipid-Anchored Membrane Proteins: Perspectives From Protein-Lipid Interactions. Mol. Memb. Biol. 19: 247-255. Martin, T. F. J. (2001). PI(4,5)P 2 Regulation of Surface Membrane Traffic. Curr. Opin. Cell Biol. 13: 493- 499. Mascaretti, O. (2003). Bacteria Versus Antibacterial Agents: An Integrated Approach. ASM Press, Washington D. C. Masuda, M., Takeda, S., Sone, M., Ohki, T., Mori, H., Kamioka, Y., and Mochizuki, N. (2006). Endophilin BAR Domain Drives Membrane Curvature By Two Newly Identified Structure-Based Mechanisms. EMBO J. 25: 2889-2897. Mateo, C. R., de Almeida, R. F. M., Loura, L. M. S., and Prieto, M. (2006). From Lipid Phases to Membrane Protein Organization: Fluorescence Methodologies in the Study of Lipid-Protein Interactions. in “Protein-Lipid Interactions: New Approaches and Emerging Concepts.” (Eds. Mateo, C. R., Gómez, J., Villalaín, J., Ros, J. M. G.) Springer-Verlag. Berlin, Germany. McIntosh, T. J., Vidal, A., and Simon, S. A. (2002). The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. in Current Topics in Membranes 52: 205-253. McLaughlin, S., Wang, J., Gambhir, A., and Murray, D. (2002). PIP 2 and Proteins: Interactions, Organization, and Information Flow. Annu. Rev. Biophys. Struct. 31: 151-175. McMahon, H. T., and Gallop, J. L. (2005). Membrane Curvature and Mechanisms of Dynamic Cell Membrane Remodeling. Nature 438: 590-596. Meijer, A. B., Spruijt, R. B., Wolfs, C. J. A. M., and Hemminga, M. A. (2001). Membrane-Anchoring Interactions of M13 Major Coat Protein. Biochemistry 40: 8815-8820. 198
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UNIVERSIDADE TÉCNICA DE LISBOA INS
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Fernandes, F., Loura, L. M. S., Fed
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Ao Pedro e Hugo, amigos de longa da
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2.2. - Peptides as models 2.3. - Am
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ABBREVIATIONS AND SYMBOL LIST ABBRE
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RESUMO RESUMO As biomembranas são
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SINOPSE SINOPSE Nas últimas duas d
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SINOPSE podem fornecer informação
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SINOPSE aceitantes. Dadores mais pr
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OUTLINE OUTLINE The last two decade
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OUTLINE membranes with a distributi
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OUTLINE BAR domains (tubulation of
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ion diffusion, as the energy requir
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acid. If no more groups are linked
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sphingomyelin, the most abundant sp
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signal for neighbouring cells to ph
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functional role in process such as
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in the L α phase, while lateral di
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1.7. Lateral heterogeneity in lipid
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the vesicle through bilayer deforma
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Figure I.9 - Depiction of the sever
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Figure I.11 - Experimentally obtain
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drying into a film and ressuspensio
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deactivating agents. Zwitterionic d
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amphipatic helices (see Section 2.3
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size corresponding to the hydrophob
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changes abruptly in the interfacial
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thickness of the bilayer (Section 1
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some α-helical membrane proteins a
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The formation of a lipid population
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homogeneous distribution of lipids
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Figure I.20 - Relative binding cons
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2.9. Lipid phase preferential parti
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In Figure I.21, theoretical simulat
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PROTEIN-PROTEIN AND PROTEIN-LIPID I
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2430 Biophysical Journal Volume 85
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2432 Fernandes et al. Coat protein
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2434 Fernandes et al. leads to an a
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2436 Fernandes et al. FIGURE 4 (A)
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2438 Fernandes et al. section of th
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2440 Fernandes et al. tein oligomer
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QUANTIFICATION OF PROTEIN-LIPID SEL
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FRET Study of Protein-Lipid Selecti
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BINDING OF INHIBITORS TO A PUTATIVE
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BINDING OF INHIBITORS TO A PUTATIVE
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INTERACTION OF THE INDOLE CLASS OF
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5272 Biochemistry, Vol. 45, No. 16,
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BINDING ASSAYS OF INHIBITORS TOWARD
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1778 F. Fernandes et al. / Biochimi
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apparently the most significant as
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110
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Introduction Quinolones are broad-s
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[9-12]. Having this into considerat
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any case, very similar, probably wi
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placement of the protein around the
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⎛ II t ⎛ R ⎞ 0 ρ () t = exp
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APPENDIX - Derivation of the FRET r
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2 2w J ( t) = '2 R − R + w / 1
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[14] L. Plançon, M. Chami, L. Lete
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acceptors) (Eqs. 4-6) (⋅-⋅-⋅)
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FIGURE 1A FIGURE 1B 130
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136
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dynamin. Soon after, the same group
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140
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142
Page 172 and 173: Introduction Control of membrane re
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Page 184 and 185: Figure Legends Fig.1: N-terminal am
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Page 202 and 203: zoxadiazol (NBD)-PC were obtained f
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Page 206 and 207: CONCLUSIONS VII CONCLUSIONS Chapter
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Page 212 and 213: CONCLUSIONS Chapter VI - Clustering
Page 214 and 215: FINAL CONSIDERATIONS AND PROSPECTS
Page 216 and 217: BIBLIOGRAPHY IX BIBLIOGRAPHY Albert
Page 218 and 219: BIBLIOGRAPHY Phosphatidylinositol 4
Page 220 and 221: BIBLIOGRAPHY Glaubitz, C., Grobner,
Page 224 and 225: BIBLIOGRAPHY Mishra, V. K., Palguna
Page 226 and 227: BIBLIOGRAPHY Pluschke, G., Hirota,
Page 228 and 229: BIBLIOGRAPHY Sperotto, M. M., and M
Page 230: BIBLIOGRAPHY Williamson, I. M., Alv
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