1 Selective serotonin reuptake inhibitors (SSRI) â sales, withdrawal ...

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On the basis of literature and a document search for this thesis I created a timeline starting from the introduction of benzodiazepines in the late 1950s up till today (table 2) illustrating the medicines life-cycle. 14
4.1. List of abbreviations ATC CPMP CSM DDD DKMA DSM EMA FDA ICD MAH MCA MHRA N05 N06 SPC SSRI Anatomical Therapeutic Chemical Classification System Committee for Proprietary Medicinal Products (EMA) Committee on Safety of Medicines Defined daily dose. The assumed average dose per day for a medicinal product used for its main indication in adults. Danish Medicines Agency Diagnostic and Statistical Manual of Mental Disorders European Medicines Agency (EU) Food and Drug Administration (USA) International Classification of Diseases Marketing authorisation holder Medicines Control Agency Medicines and Healthcare products Regulatory Agency (UK) Nervous system: antipsychotics, anxiolytics, hypnotics and sedatives Nervous system: antidepressants, psychostimulants, psycholeptics and antidementia Summary of Product Characteristics Selective serotonin reuptake inhibitor 15
Page 1 and 2: Selective serotonin reuptake inhibi
Page 3 and 4: 1. Preface and acknowledgement 1.1
Page 5 and 6: 2. Abstract Psychotropic drug use h
Page 7 and 8: 3. Danish summary Brugen af psykotr
Page 9 and 10: 4. Introduction Psychotropic medici
Page 11 and 12: It is pretty clear that the inclusi
Page 13: The first two studies led to the th
Page 17 and 18: to accept withdrawal reactions as a
Page 19 and 20: than in the former DSM-III were des
Page 21 and 22: 5. Objectives In the light of this
Page 23 and 24: including gifts, drug samples and i
Page 25 and 26: The data in the register represent
Page 27 and 28: DDD/1000 inhabitants/day Figure 1:
Page 29 and 30: general, a motivated GP in an urban
Page 31 and 32: of Diseases (ICD) is organized by t
Page 33 and 34: palpitations skin rash, itching abd
Page 35 and 36: which withdrawal reaction is one cr
Page 37 and 38: It was not possible to use a system
Page 39 and 40: http://www.mhra.gov.uk/home/groups/
Page 41 and 42: 21876/Seroxat%2C+filmovertrukne+tab
Page 43 and 44: Abraham and Davis have explored dru
Page 45 and 46: 8. Perspectives Patient safety is a
Page 47 and 48: 9. References 1. Hansen EH, Gyldmar
Page 49 and 50: 33. Classifications [Internet]. WHO
Page 51 and 52: 63. Abraham J, Davis C. Risking pub
Page 53 and 54: International Journal of Risk & Saf
Page 55 and 56: M. Nielsen and P. Gøtzsche / An an
Page 61 and 62: s_bs_banner REVIEW doi:10.1111/j.13
Page 63 and 64: 902 Margrethe Nielsen et al. RESULT
Page 65 and 66:
904 Margrethe Nielsen et al. Table
Page 67 and 68:
906 Margrethe Nielsen et al. abrupt
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908 Margrethe Nielsen et al. 40. Sc
Page 71 and 72:
Abstract Aim: Our objective was to
Page 73 and 74:
There are different views whether S
Page 75 and 76:
Results We identified 6 documents r
Page 77 and 78:
In 1998, it was stated that SSRIs d
Page 79 and 80:
having both medical and abuse poten
Page 81 and 82:
for documents that were available o
Page 83 and 84:
16. Nielsen M, Hansen EH and Gøtzs
Page 85 and 86:
Table 1: Search strategy Source Sea
Page 87 and 88:
1988 Medicines Control Agency, Comm
Page 89 and 90:
2000 Medicines Control Agency, Comm
Page 91 and 92:
2003 Meeting 16 September CSM and E
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