1 Selective serotonin reuptake inhibitors (SSRI) â sales, withdrawal ...

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2002 Ad Hoc Expert Meeting 21 November on the safety of SSRIs 2003 DKMA Danish Medicines Agency (19 June 2003). Summary of Product Characteristics for Serorex (paroxetine) http://www.produktresume.dk/docushare/dsweb/Get/Document- 14813/Serorex%2C+filmovertrukne+tabletter+20+mg.doc 2003 DKMA Lægemiddelstyrelsen (2003). Antidepressive midler under vurdering (Antidepressants under assessment). 2003 Meeting of the CSM Expert group on the safety of SSRIs held on Tuesday 22nd July. stopping but they are not drugs of dependence. The Group did not consider that withdrawal reactions and dependence were synonymous. The Group did not consider that SSRIs caused dependence. [Though abstinence reactions can occur at discontinuation, all preclinical and clinical data do not indicate that SSRIs cause dependence] [It is important to emphasize that it is about discontinuation symptoms and not actual dependence to the drugs.] The group commented that it was a challenge to disseminate the information [about withdrawal reaction] in such a way that informed patients of the risks but did not stop them taking the medication. 2003 Committee on Safety of Medicines No strong evidence has been identified to suggest that SSRIs cause other features of dependence. 2003 WHO Expert Committee on drug dependence WHO Techical Report series no 915. Thirty third report. WHO Geneve. Three SSRIs are among the 30 highest-ranking drugs in the list of Minutes SPC Article to the public because of media referring to problems with the antidepressants. Minutes Minutes Technical report
2003 Meeting 16 September CSM and Expert group on Safety of SSRIs 2003 Committee on Safety of Medicines and Expert Group on Safety of SSRIs. Minutes of the meeting held Tuesday 25 November 2003. http://www.mhra.gov.uk/home/groups/plp/documents/committeedocument/con003487.pdf 2003 Interim report of the Committee on Safety of Medicines´ Expert Working Group on Selective Serotonin Reuptake Inhibitors September 2003 2003 WHO Pharmaceutical Newsletter 2003; no 1. Drugs of abuse: Problems of data collection, definitions and liability assessment. drugs for which drug dependence has ever been reported to the Uppsala Monitoring Centre database. The group Minutes expressed concern about the lack of data on the longtern effect of SSRIs and recommended that further research on this area was required. Professor Minutes Drummond explained that he had considered to what extent the SSRIs meet the ICD-10 and DSM- IV definitions of dependence and has concluded that the extent to which SSRIs meet the criteria is much less than with other typically dependence producing drugs. Two areas of Report continual concern …. and withdrawal reactions on stopping SSRIs. However, such a Newsletter conclusion may only be drawn after a careful review of the significant number of “drug dependence” reports for SSRIs received by the ADR monitoring system and, not on the basis
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Selective serotonin reuptake inhibi
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1. Preface and acknowledgement 1.1
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2. Abstract Psychotropic drug use h
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3. Danish summary Brugen af psykotr
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4. Introduction Psychotropic medici
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It is pretty clear that the inclusi
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The first two studies led to the th
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4.1. List of abbreviations ATC CPMP
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to accept withdrawal reactions as a
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than in the former DSM-III were des
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5. Objectives In the light of this
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including gifts, drug samples and i
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The data in the register represent
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DDD/1000 inhabitants/day Figure 1:
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general, a motivated GP in an urban
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of Diseases (ICD) is organized by t
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palpitations skin rash, itching abd
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which withdrawal reaction is one cr
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It was not possible to use a system
Page 39 and 40: http://www.mhra.gov.uk/home/groups/
Page 41 and 42: 21876/Seroxat%2C+filmovertrukne+tab
Page 43 and 44: Abraham and Davis have explored dru
Page 45 and 46: 8. Perspectives Patient safety is a
Page 47 and 48: 9. References 1. Hansen EH, Gyldmar
Page 49 and 50: 33. Classifications [Internet]. WHO
Page 51 and 52: 63. Abraham J, Davis C. Risking pub
Page 53 and 54: International Journal of Risk & Saf
Page 55 and 56: M. Nielsen and P. Gøtzsche / An an
Page 61 and 62: s_bs_banner REVIEW doi:10.1111/j.13
Page 63 and 64: 902 Margrethe Nielsen et al. RESULT
Page 65 and 66: 904 Margrethe Nielsen et al. Table
Page 67 and 68: 906 Margrethe Nielsen et al. abrupt
Page 69 and 70: 908 Margrethe Nielsen et al. 40. Sc
Page 71 and 72: Abstract Aim: Our objective was to
Page 73 and 74: There are different views whether S
Page 75 and 76: Results We identified 6 documents r
Page 77 and 78: In 1998, it was stated that SSRIs d
Page 79 and 80: having both medical and abuse poten
Page 81 and 82: for documents that were available o
Page 83 and 84: 16. Nielsen M, Hansen EH and Gøtzs
Page 85 and 86: Table 1: Search strategy Source Sea
Page 87 and 88: 1988 Medicines Control Agency, Comm
Page 89: 2000 Medicines Control Agency, Comm
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