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testing strategies. Plenary presentations
focused on the toxicity pathway concept in
general, with case studies in the areas of
reproductive toxicity and skin sensitisation
(allergy). Workshop participants were
divided into three breakout groups for a
focused discussion of the scientific stateof-the-art
and of knowledge gaps and
priorities for future EU research funding in
order to develop a ‘roadmap to innovative
toxicity testing’. In the first breakout
group, general building blocks for a
pathway-based paradigm were discussed,
while the other two groups examined
reproductive toxicity and skin sensitisation
as case studies. Chapter 3 also includes
manuscripts from workshop presentations,
summary reports from the three breakout
groups, and the recommendations of the
AXLR8 Scientific Panel for a ‘roadmap to
innovative toxicity testing’—also termed
‘safety evaluation ultimately replacing
animal testing’ (‘SEURAT-2’) by DG R&I.
Thus the AXLR8 Progress Report 2011 is
again serving the ultimate goal of AXLR8
to set the stage for an in-depth discussion
on how to accelerate the transition to
a toxicity pathway-based paradigm for
chemical safety assessment through
internationally co-ordinated research and
technology development.
EXECUTIVE SUMMARY
Progress Report 2011 & AXLR8-2 Workshop Report
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