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3.4.4 Break-Out Group 3: Skin Sensitisation
The aim of BOG3 was to: 1) evaluate whether the strategy used for safety testing of skin
sensitisers using alternative approaches has been successful and the extent to which
it has addressed already the points arising from the AXLR8 2010 workshop; 2) identify
the areas were further work is needed for adequate prédiction of risks for chemicallyinduced
skin sensitisation in humans; and 3) evaluate whether the experience gained
from the research for alternatives to test skin sensitisers can be extrapolated to other
applications and other ‘nearby’ areas of safety testing, e.g., respiratory sensitisation.
Participants
Co-chairs
Nathalie Alépée, Joanna Jaworska &
Robert Landsiedel
Rapproteur
Greet Schoeters
Steven Enoch
Tuula Heinonen
Jef Hooyberghs
Manfred Liebsch
Malin Lindstedt
Gavin Maxwell
Emily McIvor
Monika Sahäfer-Korting
Klaus Schröder
Thought-Starter Questions
1. To what extent does the bullet-point list above capture the critical ‘building blocks’
of a pathway-oriented strategy for skin sensitisation toxicity testing Are there any
key science issues that have not been captured that are necessary elements to
consider
2. Which tools and technologies (e.g., databases, AOP/MoA libraries, assays, etc.)
have been used behind each of these points What tools need to be developed further
3. To what extent are EU-funded projects exploring these questions already Where
are the key gaps Where are the opportunities for international collaboration and
synergy
4. Which other aspects of sensitisation need to be further developed and covered by
alternative animal free approaches e.g., respiratory sensitisation, individual sensitivity
344 AXLR8-2 WORKSHOP REPORT
Progress Report 2011 & AXLR8-2 Workshop Report