Here - Stiftung Forschung 3R

The OECD Adverse
Outcome Pathway
Approach
A Case Study for Skin Sensitisation
Terry W Schultz 1,2 , Bob Diderich 2 & Stephen Enoch 3
1
The University of Tennessee
College of Veterinary Medicine
Knoxville, TN USA
tschultz@utk.edu
2
Organisation for Economic Co-operation and Development
Environment Directorate
Environment, Health and Safety Division
Paris, France
bob.diderich@oecd.org
3
School of Pharmacy and Chemistry
Liverpool John Moores University
Liverpool, United Kingdom
s.j.enoch@ljmu.ac.uk
Introduction
Development and implementation of more integrated approaches to assessment of
organic chemicals is a challenge facing many governing bodies. The challenge is to
develop a process which shifts, in a scientifically credible and transparent manner,
from a paradigm that requires extensive in vivo testing to a paradigm that provides a
hypothesis-driven approach which identifies specific information, especially in silico, in
chemico and in vitro, most relevant to the particular assessment. The goal is to require
only those in vivo tests that are critical to addressing the remaining uncertainties in the
assessment.
One approach to meeting this challenge being examined by the Organisation for
Economic Co-operation and Development (OECD) is the ‘adverse outcome pathway’
(AOP). An AOP represents existing knowledge concerning the linkages between a
288 AXLR8-2 WORKSHOP REPORT
Progress Report 2011 & AXLR8-2 Workshop Report