April Journal-2009.p65 - Association of Biotechnology and Pharmacy

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Current Trends in Biotechnology and Pharmacy Vol. 3 (2) 149-154, April 2009. ISSN 0973-8916 13. Ravichandran, V., Mourya, V.K. and Agrawal, R.K. (2007) QSAR study of novel 1, 1, 3 – trioxo [1, 2, 4] - thiadiazine (TTDs) analogues as potent anti-HIV agents. Arkivoc, XIV: 204-212. 14. Ravichandran, V.; Prashanthakumar, B.R., Sankar, S. and Agrawal, R.K. (2008) Comparative molecular similarity indices analysis for predicting anti-HIV activity of phenyl ethyl thiourea (PET) derivatives. Med. Chem. Res., 17: 1-11. 15. Ravichandran, V., Mourya, V.K. and Agrawal, R.K. (2007) QSAR prediction of HIV–1 reverse transcriptase inhibitory activity of benzoxazinone derivatives. Internet Electron. J. Mol. Des., 6: 363-374. 16. Ravichandran V, Mourya VK, Agrawal RK (2008) QSAR modeling of hiv-1 reverse transcriptase inhibitory activity with PETT derivatives. Digest J. Nanomat. Biostruct., 3: 9-17. 17. Ravichandran, V., Mourya, V.K. and Agrawal, R.K. (2008) Prediction of HIV-1 protease inhibitory activity of 4-hydroxy-5,6- dihydropyran-2-ones: QSAR study. J. Enzyme Inhib. Med. Chem., (Inpress). 18. Ravichandran, V., Mourya, V.K. and Agrawal, R.K. (2008) QSAR analysis of 6-aryl-2,4-dioxo-5-hexenoic acids as HIV– 154 1 integrase inhibitors. Indian J. Pharm. Edu. Res., 42: 40-47. 19. Sahu, K.K., Ravichandran, V., Jain, P.K., Sharma, S., Mourya, V.K. and Agrawal, R.K. (2008) QSAR analysis of chicoric acid derivatives as HIV–1 integrase inhibitors. Acta Chimi. Slov., 55:138-145. 20. Sahu, K.K., Ravichandran, V., Mourya, V.K. and Agrawal, R.K. (2007) QSAR analysis of caffeoyl naphthalene sulphonamide derivatives as HIV-1 Integrase inhibitors. Med. Chem. Res., 15: 418-430. 21. Prasad, J.V.N.V., Para, K.S., Tummino, P.J., Fergusion, D., McQuade, T.J., Lunney, E.A., Rapundalo, S.T., Bately, B.L., Hingoram, G., Domagala, J.M., Gracheck, S. J., Bhat, T.N., Liu, B.L., Baldwin, E.T., Erickson, J.W. and Sawyer, T.K. (1995) Nonpeptidic potent HIV-1 protease inhibitors: (4-hydroxy-6-phenyl-2-oxo-2hpyran-3-yl) thiomethanes that span P 1 – P 2 ’ subsites in a unique mode of active site binding. J. Med. Chem., 38: 898-905. 22. Tropsha, A., Gramatica, P., Gombar, V.K. (2003) The importance of being earnest: Validation is the absolute essential for successful application and interpretation of QSPR models. Quant. Struct. Act. R el., 22: 1-9. Ravichandran et al
Current Trends in Biotechnology and Pharmacy Vol. 3 (2) 155-161, April 2009. ISSN 0973-8916 Comparative UV-spectra of fermented cultural extract of antifungal-active Streptomyces isolates recovered from different ecological habitats 1 Ismail Saadoun, 1 Fouad AL-Momani, 1 Qotaiba Ababneh and 2 Shahidi Bonjar 1 Dept. of Biological Sciences, Jordan Univ. of Science and Technology, Irbid-22110, Jordan 2 Department of Plant Pathology, College of Agricultural Sciences, Bahonar University of Kerman, Kerman-Iran * For Correspondence : isaadoun@just.edu.jo Abstract UV-spectra of antifungal-active Streptomyces isolates were compared to previously reported spectra and analyzed under different extraction conditions. MU123 Streptomyces isolate from Turkey exhibited a UV spectrum similar to 23 7 isolate from Jordan with 2 maximum absorbance peaks at (226 and 260 nm) and at (220 and 260 nm), respectively. This spectrum was repeated by the C5P1-6 isolate from Jordan with 2 maximum absorbance peaks at 225- 250 and 300 nm. The aquatic species identified as S. violaceusniger showed 2 maximum absorbance peaks at 231 and 258 nm similar to the UV spectrum of a clinical isolate of actinomycetes (Streptomyces sp. 96.0333) that exhibited 2 absorbance peaks at 220-225 and 262 nm. When C1P2-6 isolate from Jordan was compared to Ir 102 from Iran under same cultural, extraction and UV analysis conditions, data revealed similar UV spectra with 2 absorbance peaks for both isolates at 200-225 and 275-300 nm. Approximately 50% of reported active screened isolates exhibit similar UV-spectra which might reflect their habitats, culture and UV analysis conditions. Comparison of UV-spectra and absorption peaks of known antibiotics to that of active Streptomyces isolates might explain the ability of the same Streptomyces sp. to produce several antibiotics. Introduction Members of the order Actinomycetales are the most abundant soil microorganisms under a wide variety of conditions. They include many species that are characterized by the production of extracellular important bioactive compounds. Majority of those strains belong to species within the genus Streptomyces which produce two– thirds of the naturally occurring antibiotics world wide. Such strains were advocated as promising agents against several pathogens and are well known for their potential to produce a large number of inhibitory metabolites used in industry, pharmacy, including: antihelminthic, antitumor, antifungal agents (3, 4, 23). Several studies on the isolation, characterization and genotyping of soil streptomycetes of Jordan have already been conducted (11, 13, 14, 15). Other studies showed the ability of different streptomycetes isolates to inhibit the growth of several multi-resistant Grampositive and Gram-negative pathogens (18, 19, 20). Experiments on the nature of the inhibitory metabolite produced by S. violaceusniger showed a maximum absorption in the UV region at 210-260 nm (16). In another study, Streptomyces isolates active against Candida albicans determined with UV-spectra absorbance peaks were either at 230 nm or 300 nm or in between (17). Some of these spectra were similar to the UV-spectra of the active Comparison of UV spectrum analysis of active streptomycetes
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