Program Book

the rarity of UM, timely completion of this large trial with embedded
correlative studies appears feasible in the multicenter setting.
Financial disclosure. None
2212 UM18
A CLINICAL PROBE FOR TRANSSCLERAL OPTICAL
SPECTROSCOPY OF INTRAOCULAR TUMOURS
J Krohn1,2, P Svenmarker3, CT Xu3, S Andersson-Engels3 (joerkroh@
online.no)
1. Department of Clinical Medicine, Section of Ophthalmology, University
of Bergen, Bergen, Norway
2. Department of Ophthalmology, Haukeland University Hospital,
Bergen, Norway
3. Department of Physics, Lund University, Lund, Sweden
Purpose
To develop a fiber optic probe for in vivo diagnosis of intraocular
tumours by means of diffuse reflectance spectroscopy, and to optimize
its geometric parameters for transmitting and receiving light through
the sclera.
Methods
Two probe parameters were investigated: the source-detector distance
and the fiber protrusion, i.e. length of the fibers extending from the probe
end. Fluorescence stained choroidal tumour phantoms in enucleated
porcine eyes were measured with diffuse reflectance- and laser-induced
fluorescence spectroscopy. To evaluate the amount of light entering the
tumour phantom, rather than merely the scleral tissue, the fluorescence
from the phantoms was compared with the transmitted excitation light.
The IOP and tissue temperature were monitored, and the scleral surface
was imaged by scanning electron microscopy.
Results. A fiber source-detector distance of 5 mm with 0 mm fiber
protrusion provided maximum contrast of light interacting with the
tumour phantom relative to light propagating between the fibers without
entering into the phantom volume. Scleral applanation by the probe led
to a mean IOP rise of 15 mm Hg. During spectroscopy, a temperature rise
of 0.3 ºC was measured between the sclera and the tumour phantom.
The indentation of the optical fibers did not cause any visible damage
to the sclera.
Conclusions. A source-detector distance of 5 mm with 0.5 mm fiber
protrusion was considered optimal in terms of clinical and spectroscopic
parameters. The study indicates that transscleral spectroscopy can be
safely performed in human eyes, without leading to unacceptable IOP
elevation, significant temperature rise, or scleral damage.
Financial disclosure. Supported by grants from the Western Norway Regional Health Authority
300 UM19
OUR EXPERIENCE WITH TRANSPUPILLARY THERMO
THERAPY FOR SUSPECTED OR SMALL CHOROIDAL
MELANOMAS
Mordechai Rosner, Iris Moroz , Josef Moisseiev, Victoria Vishnevskia-Dai
(mrosner@post.tau.ac.il)
Goldschleger Eye Institute, Sackler Faculty of Medicine, Tel-Aviv
University, Sheba Medical Center, Tel-Hashomer, Israel
Purpose. Changes in treatment approaches to choroidal melanomas
resulted in better preservation of the eyeball and the visual acuity,
UVEAL MELANOMA
Abstracts
102
without increasing the mortality. As it is assumed that the initial spread
of metastases is during the proliferating stage, it might be vital to
diagnose and treat choroidal melanomas during the very early stages.
In this presentation we summarize our experience with treatment of
posterior choroidal nevi suspected for malignant transformation or small
choroidal melanomas, less than 2.5 mm in thickness using Transpupillary
Thermo Therapy (TTT).
Methods. Six patients affected by small posterior choroidal melanoma
were treated with TTT as a sole treatment from 2007 to 2011, and are
followed up.
Results. Six patients affected by small posterior choroidal melanoma
were treated with TTT as a sole treatment from 2007 to 2011, and are
followed up.
Conclusions. TTT might be the treatment of choice for selected, very
small melanomas. However, studies with long follow-up and large
number of patients are needed to evaluate it effectiveness.
Financial disclosure. None
1842 UM20
RESECTION OF IRIS TUMOURS : INTERNAL APPROACH
Arun D. Singh M.D. (singha@ccf.org)
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic
Foundation, Cleveland, OH, USA
Purpose. To describe a novel minimally invasive surgical technique for
resection of small iris tumours.
Methods. The surgical technique is described as “Small Incision Internal
Resection and Aspiration.” Through a 3.0 mm beveled clear corneal
incision a viscoelastic is instilled into the anterior chamber. Using 25 gauge
horizontal vitrectomy scissors and vitrectomy forceps, the lesion is excised
en bloc with a visible tumour free margin. A segment of clear plastic tubing
(diameter 3.5 mm), primed with viscoelastic, is inserted into the anterior
chamber through the enlarged corneal incision. Controlled aspiration
allows removal of the entire lesion into the tube. The tube is then withdrawn
from the anterior chamber and the lesion expressed onto filter paper. The
iris defect is closed using a modified Siepser slip-knot technique. The larger
corneal incision is closed with interrupted 10-0 nylon sutures.
Results. This technique has been performed on 6 patients with localized
iris tumours (base size : 5.0-1.7 mm) (hemangioma [1] and melanoma
[5]). Reduced postoperative morbidity (inflammation, hypotony,
astigmatism) allowed rapid uneventful recovery in all cases (Va 20/20).
The histopathologic diagnosis could be established in each case and the
margins were negative in all cases.
Conclusions. Minimally invasive technique for resection of selected cases
of iris tumours avoids the potential morbidity associated with a large
corneoscleral incision allowing for rapid visual recovery.
Financial disclosure. None
1917 UM21
PLAQUE RADIOTHERAPY TREATMENT WITH RUTHE-
NIUM-106 FOR IRIS MALIGNANT MELANOMA
Amit K. Arora, Maria Tsimpida, Victoria M.L. Cohen, John L. Hungerford
(amitkarora@hotmail.com)
St. Bartholomew’s Hospital and Moorfields Eye Hospital, London
Purpose. To report results of Ruthenium-106 plaque radiotherapy for iris
malignant melanoma