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2132 OTp106 INTRAOCULAR RELAPSE OF MULTIPLE MYELOMA RESPONSIVE TO BORTEZOMIB Tero Kivelä 1923 OTp107 TUBEROUS SCLEROSIS COMPLEX: CHARACTERIZA- TION OF OCULAR MANIFESTATIONS AND CORRELA- TIONS WITH SYSTEMIC DISEASE M.E. Turell, E.I. Traboulsi, A. Gupta , A.D. Singh 248 OTp108 INTERLEUKIN LEVELS IN AQUEOUS OF UNTREATED AND TREATED EYES WITH VITREORETINAL LYMPHO- MA Jose S. Pulido, Joseph Balsanek, Brian Peters, Melissa Snyder 304 OTp109 INTRAVITREAL RITUXIMAB FOR PRIMARY INTRAOCU- LAR LYMPHOMA (PIOL) V. Kakkassery, G. Willerding, K. Jahnke, A. Korfel, U. Pleyer, N. Stübiger, A.M. Joussen EYELID, CONJUNTIVA & ORBIT Posters 66
1621 EC1 EVALUATION OF THE “HEDGEHOG” SIGNALLING PATHWAYS (SHH, PTCH-1, GLI-1 LEVELS) IN SQUAMOUS AND BASAL CELL CARCINOMAS OF THE YYELIDS AND CONJUNCTIVA Hayyam Kiratli1, MD, Ali Rıza Cenk Çelebi1, MD, Figen Söylemezoğlu2, MD (hkiratli@hacettepe.edu.tr) 1. Ocular Oncology Service, Department of Ophthalmology (and Çelebi) and 2. Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey. Purpose. To assess the role of hedgehog signalling pathways in the carcinogenesis of eyelid skin and conjunctival epithelial malignant tumors. Methods. Shh, the major secreted morphogen protein of the pathway, Ptch-1, its transmembrane receptor and Gli-1, the target gene involved in stem cell proliferation were evaluated in paraffin-embedded tissues using immunohistochemical stainings. The study was conducted on the specimens of 41 patients with eyelid basal cell carcinoma, 22 with eyelid and conjunctival squamous cell carcinoma and 12 with conjunctival intraepithelial neoplasia. For each specimen, the percentage (50%) and the intensity of stainings (graded between 0 to 3) were calculated and the scores obtained by the multiplication of the two values were analyzed using Kruskall-Wallis test. Results. The Shh and Ptch-1 expressions were statistically significantly lower in the basal cell carcinoma group. In the conjunctival squamous cell carcinoma group, the Ptch-1 score was 0 in 25% of specimens and Gli-1 score was 3 in 66% of cases. In the conjunctival intraepithelial neoplasia group, the Ptch-1 score was >2 in 66% of specimens and the Gli-1 score was 3 in 87.5% of cases. Conclusions. Ptch-1 mutations may contribute to the development of eyelid basal cell carcinoma. Alterations in the hedgehog signaling pathways may lead to transformation of the conjunctival intraepithelial neoplasia into invasive squamous cell carcinoma. Financial disclosure. None 1246 EC2 MARGIN CONTROL IN EYELID TUMOR EXCISION: IS FROZEN SECTION OPTIMAL? David T.L. Liu, Kelvin K.L. Chong, Gary M.K. Tse, N.M. Luk, Dennis S.C. Lam (david_tlliu@yahoo.com) Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong; Department of Anatomical & Cellular Pathology, the Chinese University of Hong Kong; Dermatology Institute, Department of Medicine & Therapeutics, the Chinese University of Hong Kong Purpose. To report the surgical outcomes of periocular basal cell carcinoma (BCC) patients managed with quick Mohs micrographic surgery (MMS) Methods. Prospective series of periocular BCC were enrolled and managed by quick MMS, which is a simple technique of collapsing thickness of the specimen, single sectioning and one tissue-level histopathological examination. Results. Six female and one male, with age ranged from 58 to 88 were recruited. Median operation time was 30 minutes. Five patients were free from postoperative complication. At 18 months, no patient showed sign of recurrence. EYELID, CONJUNTIVA & ORBIT Abstracts 67 Conclusions. In the strike for maximal tumor clearance and aesthetic preservation, Quick Mohs micrographic surgery may be an express surrogate for the labor-intensive conventional MMS in the management of periocular BCC. Financial disclosure. None 1407 EC3 RADIOTHERAPY FOR MANAGEMENT OF MEDIAL CANTHAL BASAL CELL CARCINOMA (BCC) Hatem Krema, Caroline Chung, Evelyn Herrmann, Rand Simpson, David Payne, Normand Laperriere (htmkrm19@yahoo.com) Ocular Oncology and Radiation Oncology Department, Princess Margaret Hospital/ UHN Toronto, Ontario, Canada Purpose. To report the efficacy and toxicity of fractionated external beam radiotherapy for management of medial canthal BCC. Methods. Retrospective case series analysis. We included consecutive patients with medial canthal BCC treated with orthovoltage radiotherapy using direct apposition technique. Patients were included whether radiotherapy was delivered as a primary treatment or for recurrent cases after surgical excision, between 1998 and 2009. Kaplan-Meier estimates were used to calculate actuarial rates. Results. Included in this study were 92 patients with a median follow-up of 70 months. The median dose was 35 Gys and the median fraction dose was 7 Gys. The local control rate was 96% for BCCs treated primarily by radiotherapy, and 78% for recurrent BCCs after prior surgery. There were transient post radiotherapy complications in 72% of patients. Chronic epiphora was present in 19% and chronic dry eye symptoms in 15 %. Conclusions. Radiotherapy provides an alternative management to surgical excision and major reconstruction procedures for medial canthal BCC, with manageable post irradiation side effects. Financial disclosure. None 1756 EC4 DOES THE SIZE OF EYELID SEBACEOUS CARCINOMA CORRELATE WITH NODAL METASTASIS AND SURVIVAL? Bita Esmaeli1, Qasiem Nasser 1, Hilda Cruz1, Melissa Felman1, Carla L. Warneke4, Doina Ivan2.3 (besmaeli@mdanderson.org) 1. Section of Ophthalmology, Department of Head and Neck Surgery, 2. Department of Pathology, 3. Department of Dermatology, 4. Department of Biostatistics The University of Texas MD Anderson Cancer Center, Houston, Texas. Purpose. To evaluate whether the American Joint Committee on Cancer (AJCC) 7th edition T designation for eyelid carcinomas correlates with lymph node metastasis, distant metastasis, and survival in patients with sebaceous carcinoma of eyelid. Methods. The records of 50 consecutive patients who were treated by the principal investigator (BE) for a diagnosis of sebaceous carcinoma of eyelid between May 1999 and August 2010 were reviewed. Each patient was staged using the AJCC 7th edition TNM (Tumor, Nodal status, Distant Metastasis) criteria based on clinical, pathologic, and radiographic data.
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XV th NH City Hotel and Tower Boliv
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List of Congress Meetings of the In
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Table of Contents Welcome address K
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Keynote Lectures Lymphoma of the oc
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The venue for the Biannual Meeting
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Buenos Aires Downtown MAP 12 Venue
Page 15 and 16: MORNING 8.30-10.10 Papers (Moderato
Page 17 and 18: 50 RES 26 USING THE GLYCOLYTIC INHI
Page 19 and 20: 2226 RES 4 NOTCH SIGNALING PROMOTES
Page 21 and 22: a reduction in the number of living
Page 23 and 24: array further detected copy number
Page 25 and 26: 615 RES 21 TRB2 AND SKP2 IN THE RET
Page 27: following treatment with 2-fluorode
Page 30 and 31: 1909 Rb14 RESULTS OF PATIENTS WITH
Page 32 and 33: Posters Retinoblastoma 2006 RBp100
Page 34 and 35: 120 RBp135 MANAGEMENT OF AN ECTOPIC
Page 36 and 37: After treatment, 10 patients lived
Page 38 and 39: Methods. Six cycles of carboplatin
Page 40 and 41: 1940 RB15 PROTON THERAPY FOR RECURR
Page 42 and 43: 4. Fluoroscopy for cannula placemen
Page 44 and 45: Methods. A retrospective chart revi
Page 46 and 47: Ruth A. Kleinerman1, Chu-ling Yu1,
Page 48 and 49: 2006 RBp100 RETINOBLASTOMA ASSESSME
Page 50 and 51: months. Mean delay between beginnin
Page 52 and 53: not associated with severity of RB.
Page 54 and 55: Conclusions. During a ten-year peri
Page 56 and 57: 30 RBp127 TREATMENT MODULATION IN R
Page 58 and 59: (follow-up 5 years). Two years afte
Page 61 and 62: 8.30-9.00 Poster presentations ECOp
Page 63 and 64: Uvea (Moderators: B. Damato, M. Sag
Page 65: Morning 8.30-9.00 Poster presentati
Page 69 and 70: Purpose. Ocular surface squamous ne
Page 71 and 72: (cargusale@yahoo.com) Oncology Serv
Page 73 and 74: of the tissues most commonly affect
Page 75 and 76: 2128 RF1 RETINOBLASTOMA David H. Ab
Page 77 and 78: Ocular Oncology Service, St Barthol
Page 79 and 80: Arturo Irarrazaval, Pablo Cazon, Os
Page 81 and 82: A CASE OF TEARING AND SWELLING OF T
Page 83 and 84: 1849 ECp101 FIVE CASES OF CARCINOMA
Page 85 and 86: patients. The isolated involvement
Page 87 and 88: exudative fluid from the hemangioma
Page 89: maximum of 7 rituximab injections.
Page 92 and 93: 153 UM14 PHENO-GENOTYPIC IDENTIFICA
Page 94 and 95: 8.30-9.00 Poster presentations UMp1
Page 96 and 97: 2253 UM1 PRELIMINARY STUDY OF VASCU
Page 98 and 99: Purpose. To determine the presence
Page 100 and 101: gene expression profile of melanocy
Page 102 and 103: the rarity of UM, timely completion
Page 104 and 105: C. Metz, T. Gkika, W. Sauerwein, N.
Page 106 and 107: Patients in the triamcinolone group
Page 108 and 109: 1350 Ump101 INDUCED EXPRESSION OF P
Page 110 and 111: Purpose. To report the Results of R
Page 112 and 113: 1547 Ump113 LONG-TERM OBSERVATIONS
Page 114 and 115: 2038 Ump119 VALUE OF DOPPLER ANALYS
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Methods. A total of 4070 patients w
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First authors Naseripour, Masood No
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