Program Book

Arturo Irarrazaval, Pablo Cazon, Oscar Croxatto
(artuira@consultoresoftalmologicos.com)
Consultores Oftalmologicos
Purpose. To show an unusual evolution of a plaque treated tumor of the
posterior pole.
Methods. A patient treated with plaque for a mushroom shaped choroidal
melanoma, with characteristic ecography, that had quick growth after
some years of stability, even after TTT adjuvant treatment.
Results. The pathology of enucleated eye shows that the tumor was a
melanocytoma
Conclusions. A choroidal melanocytoma may have an unusual form of
presentation and evolution.
Financial disclosure
None
1655 RF27
MALIGNANT TRANSFORMATION OF CELLULAR BLUE
NEVUS IN AN 8-YEAR-OLD GIRL
A P Moulin1, M Hamedani1, A Oberic1, M Mihm2, F Jakobiec3, V Prieto4, JN
Myers4, F Demont4, RJ Skoracki4, S Woodman4, B Eemaeli4. (alexandre.
moulin@fa2.ch)
1. Jules Gonin Eye Hospital, Lausanne University, Switzerland
2. Brigham and Women’s Hospital, Harvard Medical School, Boston
3. Massachussetts Eye and Ear Infirmary, Harvard Medical School,
Boston
4. MD Anderson Cancer Center, University of Texas, Houston
Purpose. To report a case of malignant transformation of blue nevus of
eyelid into melanoma of orbit in an 8-year-old girl.
Methods. Observational case report.
Results. An 8-year-old girl was referred to Jules Gonin Eye Hospital
for evaluation of an extensive blue nevus involving the right lower
eyelid, the inferior conjunctiva and the orbit with evidence of recent
growth into the orbit. Multiple palpebral and orbital biopsies were
performed. The deepest lesions were consistent with cellular blue
nevus with severe atypia. After 6 months observation, growth of the
orbital mass led to repeat biopsies which confirmed transformation
into invasive melanoma in the orbit. aCGH demonstrated a complete
gain of chromosome 6. There were no mutations of BRAF (exon 15),
GNAQ and GNA11 (exons 5). The patient was referred for evaluation
and management to the University of Texas M.D. Anderson Cancer
Center. The orbital tumor was found to involve the pterygopalatine
fossa and other skull base structures. A multidisciplinary
procedure including an orbital exenteration and skull base surgery
was performed followed 4 weeks later by proton radiotherapy.
Histopathology revealed atypical cellular blue nevus with foci of
melanoma in the posterior orbit.
Conclusions. Cellular blue nevi can rarely transform into malignant
melanoma and can involve deeper structures in the orbital apex and
skull base. To our knowledge, this may be the youngest patient to
date documented to have a malignant transformation of cellular
blue nevus into melanoma. The extent of involvement of atypical
blue nevus required a complex multidisciplinary surgical approach
followed by high-dose radiation therapy.
Financial disclosure. None
Rapid Fire Cases
Abstracts
79
1618 RF28
ORBITAL MELANOMA AND NAEVUS OF OTA
Victoria M.L. Cohen (victoria.lendrum@gmail.com)
Ocular Oncology Service, Moorfields and St Batholomew’s Hospital
London, UK.
Purpose. To report the management of an extensive orbital melanoma
in a patient with naevus of Ota
Methods. A 46-year old male with long standing pigmentation of the
eye and eyelid presented with progressive proptosis. Orbital biopsy
confirmed the presence of melanoma. Despite adjuvant radiotherapy,
the lesion continued to enlarge. The subsequent radical surgical
approach is described
Results. Melanoma was found to be infiltrating the orbital bone,
maxilla, nasopharynx and dura mata.
Conclusions. Orbital and cerebral melanoma is very rare but the most
lethal association of naevus of Ota.
Financial disclosure. None
558 RF29
MANAGEMENT OF A RARE ADNEXAL TUMOR
Sonul Mehta, MD1, John Harvey, MD, F.R.C.S.2 (sonulmehta@gmail.
com)
1. Division of Oculoplastics and Orbital Surgery, Department of
Ophthalmology and Visual Sciences, University of Toronto
2. Division of Oculoplastics and Orbital Surgery, Department of
Ophthalmology and Visual Sciences, McMaster University
Purpose. A 28 year old male who sustained a right upper brow and
eyelid laceration after an injury that presented with a non-healing
wound 3 months later. He was found to have a rare adnexal tumor.
He will be presented to the audience as an unknown for opinions on
management.
Methods. Case Study
Results. He was found to have a rare adnexal tumor that has failed
multiple reconstructions and found to have recurrence of tumor.
Conclusions. He will be presented to the audience as an unknown for
opinions on management.
Financial disclosure. None
19 RF30
AMELANOTIC CONJUNCTIVAL TUMOR - MALIGNANT OR
BENIGN?
Priscilla Ballalai, Maria C. Martins, Marcia Lowen (pbbordon@terra.com.br)
Federal University of Sao Paulo
Purpose. 82 yo female with a rapid growing conjunctival tumor
Financial disclosure. None
1809 RF31
65-YEAR OLD WOMAN WITH DIFFUSE CONJUNCTIVAL
NEOPLASM
J. William Harbour, MD (harbour@vision.wustl.edu)