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Purpose. To describe a patient with metastatic choroidal paraganglioma, locally controlled with radiotherapy. Methods. Interventional clinico-pathological case report. Systematic search of the literature. Results. A 50-year-old man presented a non-pigmented atypical choroidal mass with secondary retinal detachment in the left eye. Following incisional biopsy, the diagnosis of paraganglioma was established. Metastatic work-up revealed vertebral, mediastinal and pulmonary metastases of a non secretory, malignant paraganglioma without tracer uptake. The primary tumor was not identified. The ocular tumor regressed after stereotaxic radiotherapy. Two years later, the patient developed recurrent lesions in the contralateral eye, which were also irradiated. Conclusions. Malignant paraganglioma can metastasize in the choroid and should be included in the differential diagnosis of a non pigmented choroidal mass. Stereotaxic radiation therapy is an effective treatment modality. To our knowledge, this is the first report of a patient with choroidal paraganglioma. Financial disclosure. None Rapid Fire Cases Abstracts 82 67 RF46 MYSTERY CASE Sara Lally (saralally1@yahoo.com) Wills Eye Hospital, Philadelphia 68 RF47 MYSTERY CASE Hakan Demirci (hdemirc1@hfhs.org
1849 ECp101 FIVE CASES OF CARCINOMA METASTASIC TO THE EYELIDS Hiroya Kashiwagi1, Hirohisa Katagiri2, Takuya Takagi2, Hideki Murata2, Mitsuru Takahashi2, Toshiaki Takahashi3 , Masato Matsuzaki4 (h.kashiwagi@scchr.jp) 1. Ophthalmology, 2. Orthopedics, 3. Thoracic Oncology, and 4. Urology, of Shizuoka Cancer Center Purpose. We report 5 rare cases of carcinoma metastasis to the eyelid. Methods. We reviewed the medical records of 5 patients with metastatic eyelid carcinoma who consulted the Shizuoka Cancer Center from April 2007 to March 2011. Results. Four of the patients were male and one was female (age range, 42–71 years; average age, 62.4 years). The primary tumors were a seminal vesicle leiomyosarcoma, an occult primary neuroendocrine carcinoma, a lung cancer, occult primary sarcoma, and a renal cell carcinoma. The site of carcinoma was the upper eyelid in 3 cases and the lower in 2 cases. The renal cell carcinoma was the only tumor that was discovered before the primary lesion was found. The treatment given was complete removal in 1 case, excisional biopsy in 1case, and incisional biopsy in 3 cases. Three patients died of systemic metastatic disease, and the time to death from discovery of the lesion was 2–3 months (average, 2.3 months). The leiomyosarcoma was resistant to chemotherapy and irradiation. The occult primary sarcoma was treated with macroscopic complete extraction. Therefore, chemotherapy was administered, and it was found to be effective with no recurrence. The renal cell carcinoma showed rapid growth even after the primary carcinoma was removed completely; therefore, complete resection with a safety margin of 5 mm was performed, and no recurrence has been reported to date. Conclusions. We think that early extraction are necessary for sarcoma. Oncologists should also understand that eyelid lesions may progress even if the primary tumor was removed. Financial disclosure. None 1516 ECp102 NATURAL KILLER/T-CELL LYMPHOMAS IN OCULAR LESION Hideki Tsuji, Megumi Kobayashi, Kengo Takeuchi, Kazuhiro Oshitari, Keigo Shikishima (tsuji-tky@umin.ac.jp) The Cancer Institute Hosptal Purpose. The importance of malignant lymphomas (ML) in ocular oncology is widely known. However, NK/T ML constitute a extremely small fraction of ocular adnexal lymphomas (OAL). We show the cases of NK/T in OAL. Methods. Case reports of NK/T malignant lymphomas (ML) of medial rectus muscle (68y.o.M) and of eyelid (60 y.o. F). Results. Both cases had aggressive clinical coarse even with radiation and chemotherapy, especially the medial rectus muscle case recurred and showed poor prognosis. Conclusions. NK/T ML in OAL have different clinical course compared with MALT lymphoma. These cases suggest us about clinical and pathological varieties of OAL and each subtype ML requires each prompt therapeutic strategies. Financial disclosure. None 2337 ECp103 CONJUNCTIVAL SQUAMOUS CELL CARCINOMA EYELID, CONJUNTIVA & ORBIT Abstract Posters 83 ARISING IN IMMUNOSUPPRESSED PATIENTS (ORGAN TRANSPLANT, HUMAN IMMUNODEFICIENCY VIRUS INFECTION) Carol L. Shields, M.D., Aparna Ramasubramanian, M.D., Phoebe L. Mellen, B.S., Jerry A. Shields, M.D. (carol.shields@shieldsoncology.com) Wills Eye Institute Purpose. To describe the relationship between chronic systemic immune suppression and conjunctival squamous cell carcinoma (SCC). Methods. Surgical excision in all cases plus additional topical interferon alpha 2B and/or mitomycin Results. There were three groups of patients with chronic immunosuppression and conjunctival SCC, including post organ transplant (n=8), human immunodeficiency virus (HIV) (n=4), and systemic lupus erythematosis (SLE) on long-term corticosteroids (n=1). The transplanted organ was kidney (n=4), lung (n=2), liver (n=1), and heart (n=1). The mean patient age at presentation for the organ transplant group was 60 years and the mean interval from transplant to conjunctival SCC was 8.2 years. Management included surgical excision (n=8) plus additional topical interferon alpha 2B (n=3) and mitomycin C (n=1). Three patients showed aggressive recurrence. In the HIV group, the mean patient age at presentation was 54 years and the mean interval from HIV diagnosis to conjunctival SCC was 5 years. Management included surgical excision (n=5) plus additional topical interferon alpha 2B (n=3) and mitomycin C (n=1). One patient showed aggressive extensive recurrence. Of the 5 patients treated with excision and prompt topical interferon alpha 2B, none showed recurrence or new tumor. Conclusions. Conjunctival SCC can occur in immune suppressed patients and can be more aggressive and invasive, requiring enucleation or exenteration. Surgical resection plus topical interferon alpha 2B might reduce the risk for recurrence/new tumor. Financial disclosure. None 1822 ECp104 SQUAMOUS NEOPLASIA OF THE OCULAR SURFACE INVADING THE EYE AND ORBIT: A STUDY OF 30 CASES Eduardo F. Marback, Ediney Vila Nova Silva, Roberto L. Marback (eduardomarback@uol.com.br) Federal University of Bahia - Brazil Purpose. To evaluate cases of squamous neoplasia of the ocular surface (SNOS) with orbital or intraocular invasion that required mutilating surgery. Methods. A review in the registry book from the Ophthalmic Pathology Laboratory at Federal University of Bahia – Brazil from January 2000 to December 2009 was conducted looking for entries with histopathologic diagnosis of SNOS. Cases with intraocular or orbital invasion that required mutilating surgery (eye enucleation or orbital exenteration) were selected. Collected data included age, sex, preoperative visual acuity, duration of symptoms and presence of previous surgery. Results. From 213 cases of SNOS, 30 (14%) had conjunctival squamous cell carcinoma that necessitated mutilating surgery. Thirteen (43%) patients required eye enucleation and 17 (57%) required orbital exenteration. In the enucleation group the mean age at diagnosis was 62,9 years-old (ranging from 42 to 95), 10 (77%) patients were male, the mean duration of symptoms was 15,2 months (ranging from 3 to
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List of Congress Meetings of the In
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Table of Contents Welcome address K
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Keynote Lectures Lymphoma of the oc
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The venue for the Biannual Meeting
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Buenos Aires Downtown MAP 12 Venue
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MORNING 8.30-10.10 Papers (Moderato
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50 RES 26 USING THE GLYCOLYTIC INHI
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2226 RES 4 NOTCH SIGNALING PROMOTES
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a reduction in the number of living
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615 RES 21 TRB2 AND SKP2 IN THE RET
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following treatment with 2-fluorode
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1909 Rb14 RESULTS OF PATIENTS WITH
Page 32 and 33: Posters Retinoblastoma 2006 RBp100
Page 34 and 35: 120 RBp135 MANAGEMENT OF AN ECTOPIC
Page 36 and 37: After treatment, 10 patients lived
Page 38 and 39: Methods. Six cycles of carboplatin
Page 40 and 41: 1940 RB15 PROTON THERAPY FOR RECURR
Page 42 and 43: 4. Fluoroscopy for cannula placemen
Page 44 and 45: Methods. A retrospective chart revi
Page 46 and 47: Ruth A. Kleinerman1, Chu-ling Yu1,
Page 48 and 49: 2006 RBp100 RETINOBLASTOMA ASSESSME
Page 50 and 51: months. Mean delay between beginnin
Page 52 and 53: not associated with severity of RB.
Page 54 and 55: Conclusions. During a ten-year peri
Page 56 and 57: 30 RBp127 TREATMENT MODULATION IN R
Page 58 and 59: (follow-up 5 years). Two years afte
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Page 63 and 64: Uvea (Moderators: B. Damato, M. Sag
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Page 67 and 68: 1621 EC1 EVALUATION OF THE “HEDGE
Page 69 and 70: Purpose. Ocular surface squamous ne
Page 71 and 72: (cargusale@yahoo.com) Oncology Serv
Page 73 and 74: of the tissues most commonly affect
Page 75 and 76: 2128 RF1 RETINOBLASTOMA David H. Ab
Page 77 and 78: Ocular Oncology Service, St Barthol
Page 79 and 80: Arturo Irarrazaval, Pablo Cazon, Os
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Page 85 and 86: patients. The isolated involvement
Page 87 and 88: exudative fluid from the hemangioma
Page 89: maximum of 7 rituximab injections.
Page 92 and 93: 153 UM14 PHENO-GENOTYPIC IDENTIFICA
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Page 96 and 97: 2253 UM1 PRELIMINARY STUDY OF VASCU
Page 98 and 99: Purpose. To determine the presence
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Page 102 and 103: the rarity of UM, timely completion
Page 104 and 105: C. Metz, T. Gkika, W. Sauerwein, N.
Page 106 and 107: Patients in the triamcinolone group
Page 108 and 109: 1350 Ump101 INDUCED EXPRESSION OF P
Page 110 and 111: Purpose. To report the Results of R
Page 112 and 113: 1547 Ump113 LONG-TERM OBSERVATIONS
Page 114 and 115: 2038 Ump119 VALUE OF DOPPLER ANALYS
Page 116: Methods. A total of 4070 patients w
Page 119: First authors Naseripour, Masood No
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