Design of Simulated Moving Bed Chromatography - CPAC

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Purdue’s Platform SMB Technologies 1. Standing Wave Design and Optimization. 2. VERSE simulations. 3. Versatile SMB equipment. 4. A systematic knowledge-based method for process design and optimization.
Conc. Standing Wave Design: Binary, Ideal, Linear Systems Desorbent Feed I II III IV Extract Bed Position Raffinate = = u = u = u F u Feed I w,slow II w,fast III w,slow IV w,fast = Sε b u III 0 u II 0 u w,i a = u 0 a / ( 1 + Pd i ) = wave velocity of component i in zone a = L c / t s = port movement velocity F feed = feed flow rate u 0 a = interstitial velocity in zone a e b = inter-particle void fraction P = (1 – e b ) / e b = bed phase ratio d i = distribution coefficient of i S = column cross-sectional area
Page 1 and 2: Simulated Moving Bed Chromatography
Page 3 and 4: CONVENTIONAL CHROMATOGRAPHY A Batch
Page 5 and 6: Mechanisms of Adsorption
Page 7 and 8: Solution I- Binary Separation in a
Page 9 and 10: Advantages of SMB over Batch • On
Page 11: Key Barriers in SMB • A four-zone
Page 15 and 16: Concentration Standing Wave Design:
Page 17 and 18: VErsatile Reaction SEparation Simul
Page 19 and 20: Versatile SMB To implement complex
Page 21 and 22: Knowledge-Based Design & Optimizati
Page 23 and 24: Knowledge-Based Design of Tandem SM
Page 25 and 26: Conventional Size Exclusion Chromat
Page 27 and 28: SMB Experimental Validation : Ring
Page 29 and 30: Parameter (5,000 kg insulin / year)
Page 31 and 32: Design & Optimization (Mun et al.,
Page 33: Acknowledgements • Eli Lilly Co.

Design of Simulated Moving Bed Chromatography - CPAC

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